Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.

Pharmacokinetics of tinidazole in patients with lung infection

  • Received Date: 2000-04-25
  • OBJECTIVE To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS The concentration of tinidazole in patients'serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80:20:0 1) were used.There was a good liner relation within the range of 1~50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS The results suggested the pharmacokinetics of administrated tinidazole could be described by a linear two-compartment model.The pharmacokinetic parameters were T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0~∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L. CONCLUSIONS There was marker difference for pharmacokinetics of tinidazole among the 7 patients.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(1888) PDF downloads(501) Cited by()

Related
Proportional views

Pharmacokinetics of tinidazole in patients with lung infection

Abstract: OBJECTIVE To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS The concentration of tinidazole in patients'serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80:20:0 1) were used.There was a good liner relation within the range of 1~50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS The results suggested the pharmacokinetics of administrated tinidazole could be described by a linear two-compartment model.The pharmacokinetic parameters were T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0~∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L. CONCLUSIONS There was marker difference for pharmacokinetics of tinidazole among the 7 patients.

JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.
Citation: JIA Nuan, LIU Jun, BIAN Yan-fang, YUAN Cheng. Pharmacokinetics of tinidazole in patients with lung infection[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 372-374.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return