2000 Vol. 18, No. 6
Display Method:
2000, (6): 372-374.
Abstract:
OBJECTIVE To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS The concentration of tinidazole in patients'serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80:20:0 1) were used.There was a good liner relation within the range of 1～50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS The results suggested the pharmacokinetics of administrated tinidazole could be described by a linear two-compartment model.The pharmacokinetic parameters were T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0～∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L. CONCLUSIONS There was marker difference for pharmacokinetics of tinidazole among the 7 patients.
OBJECTIVE To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS The concentration of tinidazole in patients'serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80:20:0 1) were used.There was a good liner relation within the range of 1～50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS The results suggested the pharmacokinetics of administrated tinidazole could be described by a linear two-compartment model.The pharmacokinetic parameters were T1/2α=(2.42±1.75)h,T1/2β=(14.20±4.00)h,AUC0～∞=(219.0±83.9)mg.h/L,Vc=(26.58±11.75)L. CONCLUSIONS There was marker difference for pharmacokinetics of tinidazole among the 7 patients.
2000, (6): 379-380.
Abstract:
OBJECTIVE To establish a HPLC method for the determination of norvancomycin in cerebrospinal fluid.METHODS With tinidazole as the internal standard, the content of norvancomycin was assayed on a ODS-hypersil C18 column with a mobile phase composed of methanol-phosphate buffer solution(16:84,pH=5.0). The detection wavelength was 280nm.RESULTS Concentration compared with the peak area ratio, the linearity was obtained over the range of 1～60 μg.ml-1 (r=0.9993).The average recovery was 98.70%±2.65% and the intra-day and the inter-day RSD were within 1.73%～1.95% and 3.62～6.78% respectively.
OBJECTIVE To establish a HPLC method for the determination of norvancomycin in cerebrospinal fluid.METHODS With tinidazole as the internal standard, the content of norvancomycin was assayed on a ODS-hypersil C18 column with a mobile phase composed of methanol-phosphate buffer solution(16:84,pH=5.0). The detection wavelength was 280nm.RESULTS Concentration compared with the peak area ratio, the linearity was obtained over the range of 1～60 μg.ml-1 (r=0.9993).The average recovery was 98.70%±2.65% and the intra-day and the inter-day RSD were within 1.73%～1.95% and 3.62～6.78% respectively.
2000, (6): 381-382.
Abstract:
OBJECTIVE To establish a method to determine the content of clarithromycin capsules.METHODS High performance liquid chromatography and ultraviolet detection at 210nm were used.RESULTS Good linearity,precision and recovery were obtained.CONCLUSION The method is simple,rapid and accurately.
OBJECTIVE To establish a method to determine the content of clarithromycin capsules.METHODS High performance liquid chromatography and ultraviolet detection at 210nm were used.RESULTS Good linearity,precision and recovery were obtained.CONCLUSION The method is simple,rapid and accurately.
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