Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

XU Jun, WANG-Qinmin. Determination of norvancomycin in cerebrospinal fluid by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 379-380.
Citation: XU Jun, WANG-Qinmin. Determination of norvancomycin in cerebrospinal fluid by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 379-380.

Determination of norvancomycin in cerebrospinal fluid by HPLC

  • Received Date: 2000-07-20
  • OBJECTIVE To establish a HPLC method for the determination of norvancomycin in cerebrospinal fluid.METHODS With tinidazole as the internal standard, the content of norvancomycin was assayed on a ODS-hypersil C18 column with a mobile phase composed of methanol-phosphate buffer solution(16:84,pH=5.0). The detection wavelength was 280nm.RESULTS Concentration compared with the peak area ratio, the linearity was obtained over the range of 1~60 μg.ml-1 (r=0.9993).The average recovery was 98.70%±2.65% and the intra-day and the inter-day RSD were within 1.73%~1.95% and 3.62~6.78% respectively.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2056) PDF downloads(1462) Cited by()

Related
Proportional views

Determination of norvancomycin in cerebrospinal fluid by HPLC

Abstract: OBJECTIVE To establish a HPLC method for the determination of norvancomycin in cerebrospinal fluid.METHODS With tinidazole as the internal standard, the content of norvancomycin was assayed on a ODS-hypersil C18 column with a mobile phase composed of methanol-phosphate buffer solution(16:84,pH=5.0). The detection wavelength was 280nm.RESULTS Concentration compared with the peak area ratio, the linearity was obtained over the range of 1~60 μg.ml-1 (r=0.9993).The average recovery was 98.70%±2.65% and the intra-day and the inter-day RSD were within 1.73%~1.95% and 3.62~6.78% respectively.

XU Jun, WANG-Qinmin. Determination of norvancomycin in cerebrospinal fluid by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 379-380.
Citation: XU Jun, WANG-Qinmin. Determination of norvancomycin in cerebrospinal fluid by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2000, (6): 379-380.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return