Comparison of the differences between melatonin gelatin microspheres and solution in nasal delivery system

CHEN Jian-ming; YE Li-ka; GAO Shen; MAO Shi-rui; BI Dian-zhou

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Volume 19 Issue 5

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2001 > (5): 280-281

CHEN Jian-ming, YE Li-ka, GAO Shen, MAO Shi-rui, BI Dian-zhou. Comparison of the differences between melatonin gelatin microspheres and solution in nasal delivery system[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 280-281.

Citation:

CHEN Jian-ming, YE Li-ka, GAO Shen, MAO Shi-rui, BI Dian-zhou. Comparison of the differences between melatonin gelatin microspheres and solution in nasal delivery system[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 280-281.

Comparison of the differences between melatonin gelatin microspheres and solution in nasal delivery system

1.
Department of Pharmacy, No.202 Hospital of PLA, Shenyang 110003, China
2.
Department of pharmaceutics, College of Pharmacy, Second Military Medical University, Shanghai 200433, China
3.
Department of pharmaceutics,Shenyang Pharmaceutic University,Shenyang 110015,China

Received Date: 2001-06-10

Abstract

OBJECTIVE To compare the differences between gelatin microspheres and solution in nasal delivery system. METHODS The residence time in nasal mucosa and nasal absorption experiments were performed respectively to compare the differences between gelatin microspheres and solution. RESIJLTS The residence time of gelatin microspheres was longer than gelatin solution in nasal cavity, gelatin microspheres evidently raised melatonin nasal absorption and prolonged the retention time in blood circulation. CONCLUTION Gelatin microspheres could raise melatonin nasal absorption and would have good application prospects.
- gelatin microspheres,
- solution,
- nasally administration
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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