2001 Vol. 19, No. 5
Display Method:
2001, (5): 264-265.
Abstract:
OBJECTIVE To develop effect of tamoxifen on resistance modulators. METHODS The effects of tamoxifen on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT corlori- metric assay. RESULTS:Tamoxifen enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX and had no effect on efflux of DOX in K562 cells. CONCLUSION Tamoxifen is an effective reversal agent of multidrug resistance.
OBJECTIVE To develop effect of tamoxifen on resistance modulators. METHODS The effects of tamoxifen on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT corlori- metric assay. RESULTS:Tamoxifen enhanced the cytotoxicity of doxorubicin (DOX) to K562/DOX and had no effect on efflux of DOX in K562 cells. CONCLUSION Tamoxifen is an effective reversal agent of multidrug resistance.
2001, (5): 266-269.
Abstract:
The progress in the field of the biological activities of chlorophyll derivatives is reviewed in this paper with 20 references,their perspective in the treatment of cancer, hepatic impairment and anaemia ect. is also disussed.
The progress in the field of the biological activities of chlorophyll derivatives is reviewed in this paper with 20 references,their perspective in the treatment of cancer, hepatic impairment and anaemia ect. is also disussed.
2001, (5): 270-272.
Abstract:
OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.
OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.
2001, (5): 275-276.
Abstract:
OBJECTIVE To optimize prescriptions of phenoxymethylpenicillin potassium (VK) dispersible tablets and establishe content measuring method. METHODS Uniform design method and UV method were used. RESULTS The results were as follows:breaking time 45～90s, T50 1.09min, Td 2.07min, recovery ratio 97.54%. CONCLUSION The quality of phenoxymethylpeniniclillin potassium dispersible tablets is conform to Britain Pharmacopoeia and UV method is simple and rapid.
OBJECTIVE To optimize prescriptions of phenoxymethylpenicillin potassium (VK) dispersible tablets and establishe content measuring method. METHODS Uniform design method and UV method were used. RESULTS The results were as follows:breaking time 45～90s, T50 1.09min, Td 2.07min, recovery ratio 97.54%. CONCLUSION The quality of phenoxymethylpeniniclillin potassium dispersible tablets is conform to Britain Pharmacopoeia and UV method is simple and rapid.
2001, (5): 277-279.
Abstract:
OBJECTIVE To determine the preparation technique and quality standards of complex shark cartilage capsules. METHODS The compositions of the complex shark cartilage capsules were extracted repeatedly with different solvent from shark cartilage and chinese herbal medicines respectively. The quality standards of the capsule were established according to the Pharmacopoeia of the Peoples Republic of China(1995 ed.) and other related criterions. RESULTS and CONCLUSIONS The complex shark cartilage capsule is up to the standards of hospital preparations. The preparation technique is practicable and quality of the capsule is stable.
OBJECTIVE To determine the preparation technique and quality standards of complex shark cartilage capsules. METHODS The compositions of the complex shark cartilage capsules were extracted repeatedly with different solvent from shark cartilage and chinese herbal medicines respectively. The quality standards of the capsule were established according to the Pharmacopoeia of the Peoples Republic of China(1995 ed.) and other related criterions. RESULTS and CONCLUSIONS The complex shark cartilage capsule is up to the standards of hospital preparations. The preparation technique is practicable and quality of the capsule is stable.
2001, (5): 280-281.
Abstract:
OBJECTIVE To compare the differences between gelatin microspheres and solution in nasal delivery system. METHODS The residence time in nasal mucosa and nasal absorption experiments were performed respectively to compare the differences between gelatin microspheres and solution. RESIJLTS The residence time of gelatin microspheres was longer than gelatin solution in nasal cavity, gelatin microspheres evidently raised melatonin nasal absorption and prolonged the retention time in blood circulation. CONCLUTION Gelatin microspheres could raise melatonin nasal absorption and would have good application prospects.
OBJECTIVE To compare the differences between gelatin microspheres and solution in nasal delivery system. METHODS The residence time in nasal mucosa and nasal absorption experiments were performed respectively to compare the differences between gelatin microspheres and solution. RESIJLTS The residence time of gelatin microspheres was longer than gelatin solution in nasal cavity, gelatin microspheres evidently raised melatonin nasal absorption and prolonged the retention time in blood circulation. CONCLUTION Gelatin microspheres could raise melatonin nasal absorption and would have good application prospects.
2001, (5): 291-293.
Abstract:
OBJECTIVE To inspect the stability of compatibility of ceftazidime and diprophyline in four kinds of infusions in 6 hours at room temperature. METHODS The contents of ceftazidime in all kinds of infusions were determined by double wavelength spectrophotometry. RESULTS The contents of ceftazidime degraded less than 1% in 6 hours after ceftazidime was admixed with the four kinds of infusions alone. Ceftazidime and diprophylline admixed with the four kinds of infusions, respectively,They did not degrade further. CONCLUSION The contents of ceftazidime in these mixtures kept the relatively stability.
OBJECTIVE To inspect the stability of compatibility of ceftazidime and diprophyline in four kinds of infusions in 6 hours at room temperature. METHODS The contents of ceftazidime in all kinds of infusions were determined by double wavelength spectrophotometry. RESULTS The contents of ceftazidime degraded less than 1% in 6 hours after ceftazidime was admixed with the four kinds of infusions alone. Ceftazidime and diprophylline admixed with the four kinds of infusions, respectively,They did not degrade further. CONCLUSION The contents of ceftazidime in these mixtures kept the relatively stability.
2001, (5): 293-295.
Abstract:
OBJECTIVE To study the dissolution of pefloxacin tables. METHODS The dissolution rate of pefloxacin tablets was determined by ultraviolet spectrophotometry. At the same time, rotating basket method and oaring method ware compared. RESULTS There was signifficant difference (P<0.01) in T50 and Td between rotating basket method and oaring method. CONCLUSION Using rotating basket method to test dissolution is better than using oaring method.
OBJECTIVE To study the dissolution of pefloxacin tables. METHODS The dissolution rate of pefloxacin tablets was determined by ultraviolet spectrophotometry. At the same time, rotating basket method and oaring method ware compared. RESULTS There was signifficant difference (P<0.01) in T50 and Td between rotating basket method and oaring method. CONCLUSION Using rotating basket method to test dissolution is better than using oaring method.
2001, (5): 296-297.
Abstract:
OBJECTIVE To establish a method for the determination of baicalin in Jiangan mixture. METHODS The content of baicalin was determined by dual-wavelength TLC-Scanning method with 275nm and 365nm as the detection and reference wavelength respectively and with the upper of EtOAc: Butatone: MeOH: H2O (5:3:1:1) as developer. RESULTS: The linear range of baicalin was 0.80～2.40ug,The average recovery was 97.74%(RSD=1.23%,n=5) with linear ralationship(r=0.9990). CONCLUSIONS The method is simple and accurate,which could be used for the quality control of Jiangan mixture.
OBJECTIVE To establish a method for the determination of baicalin in Jiangan mixture. METHODS The content of baicalin was determined by dual-wavelength TLC-Scanning method with 275nm and 365nm as the detection and reference wavelength respectively and with the upper of EtOAc: Butatone: MeOH: H2O (5:3:1:1) as developer. RESULTS: The linear range of baicalin was 0.80～2.40ug,The average recovery was 97.74%(RSD=1.23%,n=5) with linear ralationship(r=0.9990). CONCLUSIONS The method is simple and accurate,which could be used for the quality control of Jiangan mixture.
2001, (5): 298-300.
Abstract:
OBJECTIVE To determine saikosaponin C in Huahai-yigan granules. METKODS A chromatography method of HPLC for the determination wan eat8blished an ODS column with methanol-water(61:39) as the me bile phase at 1.0ml/min flow-rate, detection wavelength at 203 nm. RESULTS The average recovery was 99.3% and RSD was 1.34%. CONCLUSIONS This method is available fur quality control of Huahai-yigan granules.
OBJECTIVE To determine saikosaponin C in Huahai-yigan granules. METKODS A chromatography method of HPLC for the determination wan eat8blished an ODS column with methanol-water(61:39) as the me bile phase at 1.0ml/min flow-rate, detection wavelength at 203 nm. RESULTS The average recovery was 99.3% and RSD was 1.34%. CONCLUSIONS This method is available fur quality control of Huahai-yigan granules.
2001, (5): 301-303.
Abstract:
OBJECTIVE To establish the quality control methods of tripterygium oral preparation (TOP) and study the quality and its stability. METHODS The total alkaliod and total triptolide were determined by TLC in tripterygium oral preparation,the total triptolide of tripterygium were determined by UV which alcohol was used as extraction and Al2O3 as purifying column. The stability was reached by control the pH and its relative density. RESULTS 6 batchs of tripterygium oral preparation were determined,the results indicated that the quality were stable and the total triptolides were less than that market product. CONCLUTION The methods are reliable,simple,convenient and can be used in preparation quality control in hospital.
OBJECTIVE To establish the quality control methods of tripterygium oral preparation (TOP) and study the quality and its stability. METHODS The total alkaliod and total triptolide were determined by TLC in tripterygium oral preparation,the total triptolide of tripterygium were determined by UV which alcohol was used as extraction and Al2O3 as purifying column. The stability was reached by control the pH and its relative density. RESULTS 6 batchs of tripterygium oral preparation were determined,the results indicated that the quality were stable and the total triptolides were less than that market product. CONCLUTION The methods are reliable,simple,convenient and can be used in preparation quality control in hospital.
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