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Volume 20 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2002  >  (1): 19-20

XU Zhong-yuan, LIU Shi-ting, HOU Lian-bing, CHEN Zhi-liang. Study on diclofenac sodium liposome hydrogel[J]. Journal of Pharmaceutical Practice and Service, 2002, (1): 19-20.
Citation: XU Zhong-yuan, LIU Shi-ting, HOU Lian-bing, CHEN Zhi-liang. Study on diclofenac sodium liposome hydrogel[J]. Journal of Pharmaceutical Practice and Service, 2002, (1): 19-20.
shu

Study on diclofenac sodium liposome hydrogel

  • Department of Pharmaceutics Science of Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China

  • Received Date: 2000-07-29
  • OBJECTIVE To prepare a liposome hydrogel of diclofenac sodium(DCS) and evaluate it. METHODS The DCS liposomes were prepared by the conventional thin film hydration method at first, to which the carbopol was added as a support base for preparation of the hydrogel of DCS. An one-order derivative UV spectrophotometry was established to evaluate the DCS in hydrogel.RESULTS The average recoveries of three samples were (101.1±0.86)%,(99.90±1.04)%和(100.5±0.91)%, respectively and the average encapsulation efficiency of liposomes is 43.6% after separated by gel minicolumn. The particle sizes of liposomes were determined by a coulter counter and d50 was 1.37μm. In stability of test, the hydrogel was stored for 0.5, 1, 3 or 6 months at 4℃ or at room temperature, and the encapsulated efficiency of liposomes was decreased by 4.4% or 6.8% respectively after six months.CONCLUTION:It is feasible to prepare a liposome hydrogel of DCS after an initial evaluation.
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Study on diclofenac sodium liposome hydrogel

  • Department of Pharmaceutics Science of Nanfang Hospital, The First Military Medical University, Guangzhou 510515, China
  • Received Date: 2000-07-29

Abstract: OBJECTIVE To prepare a liposome hydrogel of diclofenac sodium(DCS) and evaluate it. METHODS The DCS liposomes were prepared by the conventional thin film hydration method at first, to which the carbopol was added as a support base for preparation of the hydrogel of DCS. An one-order derivative UV spectrophotometry was established to evaluate the DCS in hydrogel.RESULTS The average recoveries of three samples were (101.1±0.86)%,(99.90±1.04)%和(100.5±0.91)%, respectively and the average encapsulation efficiency of liposomes is 43.6% after separated by gel minicolumn. The particle sizes of liposomes were determined by a coulter counter and d50 was 1.37μm. In stability of test, the hydrogel was stored for 0.5, 1, 3 or 6 months at 4℃ or at room temperature, and the encapsulated efficiency of liposomes was decreased by 4.4% or 6.8% respectively after six months.CONCLUTION:It is feasible to prepare a liposome hydrogel of DCS after an initial evaluation.

XU Zhong-yuan, LIU Shi-ting, HOU Lian-bing, CHEN Zhi-liang. Study on diclofenac sodium liposome hydrogel[J]. Journal of Pharmaceutical Practice and Service, 2002, (1): 19-20.
Citation: XU Zhong-yuan, LIU Shi-ting, HOU Lian-bing, CHEN Zhi-liang. Study on diclofenac sodium liposome hydrogel[J]. Journal of Pharmaceutical Practice and Service, 2002, (1): 19-20.
shu

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