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Volume 20 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2002  >  (6): 338-340

ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.
Citation: ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.
shu

Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain

  • 1.

    Kunming Military General Hospital, Kunming 650032, China

  • 2.

    The Pharmaceutical Department of Dali Medical University

  • Received Date: 2002-08-27
  • OBJECTIVE To study effect of hypericum wightianum extracts on synapse reuptake of dopamine in rat brain striatum. METHODS The inhibition experiment of reuptaking [3H]-dopamine on brain striatum synapse of rat has been adopted. The activity was evaluated by assaying quantity of reuptaking(cmp) and the inhibition percentage. RESULTS The average inhibition percentage and IC50 of Hypericum Wightianum extract group,are respectively 65% and 113.25 mg/ml and for St. Johns 61% and 28.29mg/ml-1 and for Wort group are. CONCLUSION Hypericum Wightianum extract group and antidepressant preparation St. John's Wort group both showed inhibition activity on brain striatum synapse reuptaking dopamine and have no statistics significance between the two groups.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain

  • 1. Kunming Military General Hospital, Kunming 650032, China
  • 2. The Pharmaceutical Department of Dali Medical University
  • Received Date: 2002-08-27

Abstract: OBJECTIVE To study effect of hypericum wightianum extracts on synapse reuptake of dopamine in rat brain striatum. METHODS The inhibition experiment of reuptaking [3H]-dopamine on brain striatum synapse of rat has been adopted. The activity was evaluated by assaying quantity of reuptaking(cmp) and the inhibition percentage. RESULTS The average inhibition percentage and IC50 of Hypericum Wightianum extract group,are respectively 65% and 113.25 mg/ml and for St. Johns 61% and 28.29mg/ml-1 and for Wort group are. CONCLUSION Hypericum Wightianum extract group and antidepressant preparation St. John's Wort group both showed inhibition activity on brain striatum synapse reuptaking dopamine and have no statistics significance between the two groups.

ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.
Citation: ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.
shu

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