Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain
- Received Date: 2002-08-27
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Key words:
- Hypericum Wightianum /
- dopamine /
- reuptake /
- inhibition percentage
Abstract: OBJECTIVE To study effect of hypericum wightianum extracts on synapse reuptake of dopamine in rat brain striatum. METHODS The inhibition experiment of reuptaking [3H]-dopamine on brain striatum synapse of rat has been adopted. The activity was evaluated by assaying quantity of reuptaking(cmp) and the inhibition percentage. RESULTS The average inhibition percentage and IC50 of Hypericum Wightianum extract group,are respectively 65% and 113.25 mg/ml and for St. Johns 61% and 28.29mg/ml-1 and for Wort group are. CONCLUSION Hypericum Wightianum extract group and antidepressant preparation St. John's Wort group both showed inhibition activity on brain striatum synapse reuptaking dopamine and have no statistics significance between the two groups.
Citation: | ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340. |