Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.
Citation: ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.

Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain

  • Received Date: 2002-08-27
  • OBJECTIVE To study effect of hypericum wightianum extracts on synapse reuptake of dopamine in rat brain striatum. METHODS The inhibition experiment of reuptaking [3H]-dopamine on brain striatum synapse of rat has been adopted. The activity was evaluated by assaying quantity of reuptaking(cmp) and the inhibition percentage. RESULTS The average inhibition percentage and IC50 of Hypericum Wightianum extract group,are respectively 65% and 113.25 mg/ml and for St. Johns 61% and 28.29mg/ml-1 and for Wort group are. CONCLUSION Hypericum Wightianum extract group and antidepressant preparation St. John's Wort group both showed inhibition activity on brain striatum synapse reuptaking dopamine and have no statistics significance between the two groups.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2466) PDF downloads(2028) Cited by()

Related
Proportional views

Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain

Abstract: OBJECTIVE To study effect of hypericum wightianum extracts on synapse reuptake of dopamine in rat brain striatum. METHODS The inhibition experiment of reuptaking [3H]-dopamine on brain striatum synapse of rat has been adopted. The activity was evaluated by assaying quantity of reuptaking(cmp) and the inhibition percentage. RESULTS The average inhibition percentage and IC50 of Hypericum Wightianum extract group,are respectively 65% and 113.25 mg/ml and for St. Johns 61% and 28.29mg/ml-1 and for Wort group are. CONCLUSION Hypericum Wightianum extract group and antidepressant preparation St. John's Wort group both showed inhibition activity on brain striatum synapse reuptaking dopamine and have no statistics significance between the two groups.

ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.
Citation: ZHAO Jing, HE Hong-Jing, GAO Wei, LI Quan-Hong, ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. Journal of Pharmaceutical Practice and Service, 2002, (6): 338-340.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return