Simultaneously determination of diclofenac sodium and chlorphenamine maleate by HPLC

Key words: 
• HPLC /
• Ganmaotong tablet /
• diclofenac sodium /
• chlorphenamin maleate

Abstract: OBJECTIVE To establish a HPLC method for simultaneously determination of diclofenac sodium and chlorphenamine maleate. METHODS The content of the Ganmaotong was determined by reverse HPLC using UV detector at wavelength of 264nm. RESULTS The method was linear over the ranger of 0.024～0.24mg·ml^-1(diclofenac sodium) and 0.004～0.04mg·ml^-1(chlorphenamine maleate). The mean recovery was 100.89% and 99.04%, RSD,0.58% and 0.74%. CONCLUSION The method was simple rapid and precise. It was suitable for quantitative analysis of the Ganmaotong tablet.