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Volume 21 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2003  >  (6): 367-369

LI Bing, HU De-fu, LIU Fei. HPLC determination of promethazine hydrocloride and chlordiazepoxide in Fu-fang Luobuma Pian I[J]. Journal of Pharmaceutical Practice and Service, 2003, (6): 367-369.
Citation: LI Bing, HU De-fu, LIU Fei. HPLC determination of promethazine hydrocloride and chlordiazepoxide in Fu-fang Luobuma Pian I[J]. Journal of Pharmaceutical Practice and Service, 2003, (6): 367-369.
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HPLC determination of promethazine hydrocloride and chlordiazepoxide in Fu-fang Luobuma Pian I

  • Shandong Institute for Drug Control, Jinan 250012, China

  • Received Date: 2003-10-28
  • OBJECTIVE Promethazine Hydrocloride and Chlordiazepoxide were determined by HPLC in Fu-fang Luotuma Pian I. METHODS Phenomenex - ODS3 Column(250×4. 60mm,5μm),the mobile phase consisted of a mixtur mixture of methanol-phosphate buffer(dissolved 2.64g NH4H2P04 in 1000mL water adjusted pH to 3.0 with H3PO4)(55:45)at a flow rate of 1.0 mL/min,detection was done at 250nm,the injection volume was 20μL. RESULTS:The method offered good linearity 5.1-60.8μg/mL for promethazine hydrocloride(r=1.0000), and 5.2-60.4μg/mL for chlordiazepoxide(r=0.9999).The average recovery rates were 99.5% and 101.2% respectively. CONCLUSION This method is accurate and reliable for the quality control of this compound preparation.
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HPLC determination of promethazine hydrocloride and chlordiazepoxide in Fu-fang Luobuma Pian I

  • Shandong Institute for Drug Control, Jinan 250012, China
  • Received Date: 2003-10-28

Abstract: OBJECTIVE Promethazine Hydrocloride and Chlordiazepoxide were determined by HPLC in Fu-fang Luotuma Pian I. METHODS Phenomenex - ODS3 Column(250×4. 60mm,5μm),the mobile phase consisted of a mixtur mixture of methanol-phosphate buffer(dissolved 2.64g NH4H2P04 in 1000mL water adjusted pH to 3.0 with H3PO4)(55:45)at a flow rate of 1.0 mL/min,detection was done at 250nm,the injection volume was 20μL. RESULTS:The method offered good linearity 5.1-60.8μg/mL for promethazine hydrocloride(r=1.0000), and 5.2-60.4μg/mL for chlordiazepoxide(r=0.9999).The average recovery rates were 99.5% and 101.2% respectively. CONCLUSION This method is accurate and reliable for the quality control of this compound preparation.

LI Bing, HU De-fu, LIU Fei. HPLC determination of promethazine hydrocloride and chlordiazepoxide in Fu-fang Luobuma Pian I[J]. Journal of Pharmaceutical Practice and Service, 2003, (6): 367-369.
Citation: LI Bing, HU De-fu, LIU Fei. HPLC determination of promethazine hydrocloride and chlordiazepoxide in Fu-fang Luobuma Pian I[J]. Journal of Pharmaceutical Practice and Service, 2003, (6): 367-369.
shu

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