Determination of dissolution of sibutramine hydrochloride tablets by HPLC

GAO Su-ying CHEN Xue-fan

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Volume 21 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2003 > (6): 371-373

GAO Su-ying CHEN Xue-fan, . Determination of dissolution of sibutramine hydrochloride tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2003, (6): 371-373.

Citation:

GAO Su-ying CHEN Xue-fan, . Determination of dissolution of sibutramine hydrochloride tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2003, (6): 371-373.

Determination of dissolution of sibutramine hydrochloride tablets by HPLC

GAO Su-ying CHEN Xue-fan,

Zhejiang Institute for Drug Control, Hangzhou 310004, China

Received Date: 2003-10-28

Abstract

OBJECTIVE Dissolution of sibutramine hydrochloride tablet was determinated by HPLC. The chromatography conditions were as follows:Column, Shimadzu VP-ODS; mobile phase:methol -0.05mol/L KH₂PO₄(adjusted to pH 3.0 with H₃P0₄)(70:30);velocity of flow:1mL/min;detection wavelength:223nm. The linear ranges were 5.0-50.0μg/mL. The average recoveries were 100.6%.
- sibutramine hydrochloride,
- dissolution
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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