Determination of dissolution of sibutramine hydrochloride tablets by HPLC
- Received Date: 2003-10-28
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Key words:
- sibutramine hydrochloride /
- dissolution
Abstract: OBJECTIVE Dissolution of sibutramine hydrochloride tablet was determinated by HPLC. The chromatography conditions were as follows:Column, Shimadzu VP-ODS; mobile phase:methol -0.05mol/L KH2PO4(adjusted to pH 3.0 with H3P04)(70:30);velocity of flow:1mL/min;detection wavelength:223nm. The linear ranges were 5.0-50.0μg/mL. The average recoveries were 100.6%.
Citation: | GAO Su-ying CHEN Xue-fan, . Determination of dissolution of sibutramine hydrochloride tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2003, (6): 371-373. |