Simultantous determination of salicylic acid and ketoconzole in the Fukang balm by HPLC
- Received Date: 2003-05-23
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Key words:
- HPLC /
- Salicylic acid /
- kefoconazole
Abstract: Objective To establish a HPLC method for determine of salicylic acid and ketoconazole in the Fukang balm.Methods C18 column was adopted as stationary phase, solvent mixiure composed of acetonitrile-methanol-2% ammonium acetate (14:43:43) was used as mobile phase, the detection wavelength was 235nm, the temperature of column was 30℃. Result Salicylic acid had a good linearity (r=0.9999) in the range of 0.5~2.5mg/mL, the mean recovery was 99.8%, and RSD=0.64%(n=9). Ketoconazole had a good linearity (r=0.9999) in the range of 0.5~2.5mg/mL, the mean recovery was 100.6%, and RSD=0.86%(n=9). Conclusion The above method is simple, sensitive and accurate.
Citation: | SHENG Guo-rong, XIE Yong. Simultantous determination of salicylic acid and ketoconzole in the Fukang balm by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (1): 5-7. |