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YANG Hui-yuan, LE Jian, CHEN Gui-liang. Determination of dissolution of cloxacillin sodium capsule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 83-85.
Citation: YANG Hui-yuan, LE Jian, CHEN Gui-liang. Determination of dissolution of cloxacillin sodium capsule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 83-85.

Determination of dissolution of cloxacillin sodium capsule by HPLC

  • Received Date: 2003-08-21
  • Objective To establish a method for determine the dissolution of cloxacillin sodium capsule. Methods Separations were performed on a Lichrospher C18 (octadecyl silicane) column, using 0.02mol/L KH2PO4 solution(adjust to pH 5.0 with 8N sodium hydroxide)-aeetonitrile(75:25) as the mobile phase, the detection wavelength was 225nm. Result: The method showed the good linearity within the concentration range of 20.00~200.0μg/mL (r=0.9999 ) in assay. The average recovery was 100.4% (RSD=0.3%). The method of dissolution complies with Chinese pharmacopeia(Vol Ⅱ, 2000). Conclusion The method is accurate and simple, and suitable for the quality control of dissolution of cloxaeillin sodium capsule.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of dissolution of cloxacillin sodium capsule by HPLC

Abstract: Objective To establish a method for determine the dissolution of cloxacillin sodium capsule. Methods Separations were performed on a Lichrospher C18 (octadecyl silicane) column, using 0.02mol/L KH2PO4 solution(adjust to pH 5.0 with 8N sodium hydroxide)-aeetonitrile(75:25) as the mobile phase, the detection wavelength was 225nm. Result: The method showed the good linearity within the concentration range of 20.00~200.0μg/mL (r=0.9999 ) in assay. The average recovery was 100.4% (RSD=0.3%). The method of dissolution complies with Chinese pharmacopeia(Vol Ⅱ, 2000). Conclusion The method is accurate and simple, and suitable for the quality control of dissolution of cloxaeillin sodium capsule.

YANG Hui-yuan, LE Jian, CHEN Gui-liang. Determination of dissolution of cloxacillin sodium capsule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 83-85.
Citation: YANG Hui-yuan, LE Jian, CHEN Gui-liang. Determination of dissolution of cloxacillin sodium capsule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 83-85.

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