Determination of dissolution of cloxacillin sodium capsule by HPLC
- Received Date: 2003-08-21
-
Key words:
- cloxacillin sodium /
- HPLC /
- dissolution
Abstract: Objective To establish a method for determine the dissolution of cloxacillin sodium capsule. Methods Separations were performed on a Lichrospher C18 (octadecyl silicane) column, using 0.02mol/L KH2PO4 solution(adjust to pH 5.0 with 8N sodium hydroxide)-aeetonitrile(75:25) as the mobile phase, the detection wavelength was 225nm. Result: The method showed the good linearity within the concentration range of 20.00~200.0μg/mL (r=0.9999 ) in assay. The average recovery was 100.4% (RSD=0.3%). The method of dissolution complies with Chinese pharmacopeia(Vol Ⅱ, 2000). Conclusion The method is accurate and simple, and suitable for the quality control of dissolution of cloxaeillin sodium capsule.
Citation: | YANG Hui-yuan, LE Jian, CHEN Gui-liang. Determination of dissolution of cloxacillin sodium capsule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 83-85. |