2004 Vol. 22, No. 2
Display Method:
2004, (2): 65-67.
Abstract:
Objective To review the mechanisms of action of thiazolidinediones, clinical efficacy in patients with type 2 diabetes mellitus, effects on insulin sensitivity, side-effects and guideline for the clinical use of thiazolidinediones. Methods Analyze the correlated literature at home and abroad. Results Thiazolidinediones improve insulin sensitivity of patients with insulin resistance and type 2 diabetes mellitus through several mechanisms. Conclusion Thiazolidinediones are very valuable in clinic, but patient should pay attention to their adverse effects.
Objective To review the mechanisms of action of thiazolidinediones, clinical efficacy in patients with type 2 diabetes mellitus, effects on insulin sensitivity, side-effects and guideline for the clinical use of thiazolidinediones. Methods Analyze the correlated literature at home and abroad. Results Thiazolidinediones improve insulin sensitivity of patients with insulin resistance and type 2 diabetes mellitus through several mechanisms. Conclusion Thiazolidinediones are very valuable in clinic, but patient should pay attention to their adverse effects.
2004, (2): 68-72.
Abstract:
The extraction, sample clean-up and analytical techniques of pesticide residues in traditional Chinese medicines (TCMs) are reviewed, and the application of several new extraction, sample clean-up and analytical techniques in TCMs are discussed.
The extraction, sample clean-up and analytical techniques of pesticide residues in traditional Chinese medicines (TCMs) are reviewed, and the application of several new extraction, sample clean-up and analytical techniques in TCMs are discussed.
2004, (2): 73-76.
Abstract:
Objective To introduce the research about C60 and its derivative in the domain of medicine in the recent years. Methods The structual modification of C60 and Fullerene's bioactivity, impacting mechanism and the prospect of application were summarized. Results and Conclusion As a new material, C60 and its derivatives have a much better future in the domain of medicine.
Objective To introduce the research about C60 and its derivative in the domain of medicine in the recent years. Methods The structual modification of C60 and Fullerene's bioactivity, impacting mechanism and the prospect of application were summarized. Results and Conclusion As a new material, C60 and its derivatives have a much better future in the domain of medicine.
2004, (2): 77-78,93.
Abstract:
Objective To simultaneous determination of two main components in the compound Baichuanpeng tablet without any separation. Methods The convolution spectrometry of computer information process technology was used based on convolution spectrometry. Result The mean recoveries and RSD of ephedrine hydrochloridum and diphenhydramini hydrochloridum were 100.77%, 0.82% and 94.49%, 2.55%, respectively. Conclusion The method is used for qualitative control of compound Baichuanpeng tablets. The method was simple, rapid and accuracy.
Objective To simultaneous determination of two main components in the compound Baichuanpeng tablet without any separation. Methods The convolution spectrometry of computer information process technology was used based on convolution spectrometry. Result The mean recoveries and RSD of ephedrine hydrochloridum and diphenhydramini hydrochloridum were 100.77%, 0.82% and 94.49%, 2.55%, respectively. Conclusion The method is used for qualitative control of compound Baichuanpeng tablets. The method was simple, rapid and accuracy.
2004, (2): 79-80.
Abstract:
Objective To study the susceptibilities in vitro of the Candida collected from sputum of respiratory tract infectious to 5 species of antifungal drugs, and offer reference for the clinical treatment. Methods The MIC of 43 strains of Candida to fluconazole tablets fiuconazole injectio, intraconazole capsules, allimin injectio were tested by broth microdilution methods according to the National Committee of Clinical Laboratory Standard Recommendations. Results The MIC of fluconazole was 0.8～100μg/mL and 83.7%(36/43) was susceptible; The MIC of fluconazole injectio 6.25～25μg/mL and 100% was susceptible, itraconazle capsules 2.5～10μg/mL and 90.7% was susceptible, allimin injectio 4.69～18.75μg/mL and 100% was susceptible; allimin liquid 0.78～100mg/mL and 88.4% were susceptible. Conclusion We can infer that it was effective for the deep infectious patients for Candida with 12.5μg or more dose of fluconazole injectio or allimin injectious.
Objective To study the susceptibilities in vitro of the Candida collected from sputum of respiratory tract infectious to 5 species of antifungal drugs, and offer reference for the clinical treatment. Methods The MIC of 43 strains of Candida to fluconazole tablets fiuconazole injectio, intraconazole capsules, allimin injectio were tested by broth microdilution methods according to the National Committee of Clinical Laboratory Standard Recommendations. Results The MIC of fluconazole was 0.8～100μg/mL and 83.7%(36/43) was susceptible; The MIC of fluconazole injectio 6.25～25μg/mL and 100% was susceptible, itraconazle capsules 2.5～10μg/mL and 90.7% was susceptible, allimin injectio 4.69～18.75μg/mL and 100% was susceptible; allimin liquid 0.78～100mg/mL and 88.4% were susceptible. Conclusion We can infer that it was effective for the deep infectious patients for Candida with 12.5μg or more dose of fluconazole injectio or allimin injectious.
2004, (2): 81-82.
Abstract:
Objective Ques suitable associating medications to reduce the drug tolerance of antibiotics. Methods Use ten species of common antibiotics alone or synapse to compose with seven species of common bacteria which causing diseases. Results and Conclusion Erythrocin has a strong inhibition action to pathogenicity coccus. Gentamycin has a strong inhibition action to pathogenicity rods. Most antibiotics have transparent synergistic actions with erythrocin or gentamycin. But gentamycin unite with penicillin is not suitable.
Objective Ques suitable associating medications to reduce the drug tolerance of antibiotics. Methods Use ten species of common antibiotics alone or synapse to compose with seven species of common bacteria which causing diseases. Results and Conclusion Erythrocin has a strong inhibition action to pathogenicity coccus. Gentamycin has a strong inhibition action to pathogenicity rods. Most antibiotics have transparent synergistic actions with erythrocin or gentamycin. But gentamycin unite with penicillin is not suitable.
2004, (2): 83-85.
Abstract:
Objective To establish a method for determine the dissolution of cloxacillin sodium capsule. Methods Separations were performed on a Lichrospher C18 (octadecyl silicane) column, using 0.02mol/L KH2PO4 solution(adjust to pH 5.0 with 8N sodium hydroxide)-aeetonitrile(75:25) as the mobile phase, the detection wavelength was 225nm. Result: The method showed the good linearity within the concentration range of 20.00～200.0μg/mL (r=0.9999 ) in assay. The average recovery was 100.4% (RSD=0.3%). The method of dissolution complies with Chinese pharmacopeia(Vol Ⅱ, 2000). Conclusion The method is accurate and simple, and suitable for the quality control of dissolution of cloxaeillin sodium capsule.
Objective To establish a method for determine the dissolution of cloxacillin sodium capsule. Methods Separations were performed on a Lichrospher C18 (octadecyl silicane) column, using 0.02mol/L KH2PO4 solution(adjust to pH 5.0 with 8N sodium hydroxide)-aeetonitrile(75:25) as the mobile phase, the detection wavelength was 225nm. Result: The method showed the good linearity within the concentration range of 20.00～200.0μg/mL (r=0.9999 ) in assay. The average recovery was 100.4% (RSD=0.3%). The method of dissolution complies with Chinese pharmacopeia(Vol Ⅱ, 2000). Conclusion The method is accurate and simple, and suitable for the quality control of dissolution of cloxaeillin sodium capsule.
2004, (2): 85-87.
Abstract:
Objective To establish a method to determine the Glycyrrhizic acid in Compound Anemone rivularis tablets. Methods Using HPLC with C18 column and mobile phase of methanol-0.2mol/L ammonium acetate solution-glacial acetic acid(53:47:1) with flow rate of 1.0 mL/min, the detection wavelength was 250nm. Result The linear range was 0.0520. 468mg/mL for ammonium glycyrrhizinate (r=0.9996), good linearity, precision and recovery were obtained. Conclusion The method is simple, rapid and accurate and could be used for quality control of compound anemone rivularis tablets.
Objective To establish a method to determine the Glycyrrhizic acid in Compound Anemone rivularis tablets. Methods Using HPLC with C18 column and mobile phase of methanol-0.2mol/L ammonium acetate solution-glacial acetic acid(53:47:1) with flow rate of 1.0 mL/min, the detection wavelength was 250nm. Result The linear range was 0.0520. 468mg/mL for ammonium glycyrrhizinate (r=0.9996), good linearity, precision and recovery were obtained. Conclusion The method is simple, rapid and accurate and could be used for quality control of compound anemone rivularis tablets.
2004, (2): 88-91.
Abstract:
Objective To establish a light observation method for determination of particulate matter in small volume injections and sterile powder for injection. Methods The average numbers of particles at≥10μm and at≥25μm in diameter in each unit were counted, using the sampling plans of the entire unit volume sample, the pooled sample and the diluting sample with an appropriate diluent. Results The different data were obtained with different sampling plans, and various results were found between two instruments. Most of parenral injection samples met the requirements, i. e. not more than 6000 at≥10μm and not more than 600 at≥25μm were found per vial. Conclusions The sampling method should be specified in the individual monographs. Small volume injections may be tested using the pooled sample and the diluting sample with an appropriate diluent and sterile powder for injection should be dissolved and diluted with the specified volume of filtered water or an appropriate filtered diluent based on consideration of product characteristics.
Objective To establish a light observation method for determination of particulate matter in small volume injections and sterile powder for injection. Methods The average numbers of particles at≥10μm and at≥25μm in diameter in each unit were counted, using the sampling plans of the entire unit volume sample, the pooled sample and the diluting sample with an appropriate diluent. Results The different data were obtained with different sampling plans, and various results were found between two instruments. Most of parenral injection samples met the requirements, i. e. not more than 6000 at≥10μm and not more than 600 at≥25μm were found per vial. Conclusions The sampling method should be specified in the individual monographs. Small volume injections may be tested using the pooled sample and the diluting sample with an appropriate diluent and sterile powder for injection should be dissolved and diluted with the specified volume of filtered water or an appropriate filtered diluent based on consideration of product characteristics.
2004, (2): 92-93.
Abstract:
Objective To establish an UV spectrophotometry method to determine the contents of loxoprofen sodium tablets. Methods The water was used as solvent. The detection wavelength was set at 223nm. Results The calibration curve was linear in the range from 4.016 to 16.064μg/mL, r=0.9997. The average recovery was 98.81% and the RSD was 1.29%(n=5). Conclusion The method is accurate, rapid and simple for the quality control of loxoprofen sodium tablets.
Objective To establish an UV spectrophotometry method to determine the contents of loxoprofen sodium tablets. Methods The water was used as solvent. The detection wavelength was set at 223nm. Results The calibration curve was linear in the range from 4.016 to 16.064μg/mL, r=0.9997. The average recovery was 98.81% and the RSD was 1.29%(n=5). Conclusion The method is accurate, rapid and simple for the quality control of loxoprofen sodium tablets.
2004, (2): 98-101.
Abstract:
Objective To summarize the advances in research on the chemical components, pharmacological activity and clinica use of Hypericum japonicum injection in recent years. Methods The related literature at home and abroad was collected and summarized. Results There have been extracted over 50 chemical components from Hypericum japonicum. The pharmacological activity of Hypericum japonicum are widely proved in antibacteria, protection of liver, anticancer, and cardiovascular system action. As a clinical parenteral solution, it was used for treatment of urgent and chronic hepatitis. Concluslon Hypericum japonicum contains rich chemical components, and father research would be done.
Objective To summarize the advances in research on the chemical components, pharmacological activity and clinica use of Hypericum japonicum injection in recent years. Methods The related literature at home and abroad was collected and summarized. Results There have been extracted over 50 chemical components from Hypericum japonicum. The pharmacological activity of Hypericum japonicum are widely proved in antibacteria, protection of liver, anticancer, and cardiovascular system action. As a clinical parenteral solution, it was used for treatment of urgent and chronic hepatitis. Concluslon Hypericum japonicum contains rich chemical components, and father research would be done.
2004, (2): 101-103.
Abstract:
Objective To review the biological activities of the polysaccharides from the sea cucumber. Methods The related literature reference was consuhed. Results The polysaccharides of the sea cucumber have many pharmacological functions, such as anticruor, antitumour, immune adjust, anticaducity activity. Conclusion It is clear that the polysaccharides of the sea cucumber has many pharmacological functions. The polysaccharides of the sea cucumber has a better biological activity.
Objective To review the biological activities of the polysaccharides from the sea cucumber. Methods The related literature reference was consuhed. Results The polysaccharides of the sea cucumber have many pharmacological functions, such as anticruor, antitumour, immune adjust, anticaducity activity. Conclusion It is clear that the polysaccharides of the sea cucumber has many pharmacological functions. The polysaccharides of the sea cucumber has a better biological activity.
2004, (2): 106-107.
Abstract:
Objective To evaluate the economic effectiveness of 3 therapeutic schemes for lower respiratory tract infection in the elderly. Methods Three schemes of the treatment of lower respiratory tract infection in the elderly from literatrure cefoperazone/sulbactam(A), imipenem/cilastatin(B), ceftazidime(C) were selected. Data was evaluated using the pharmacoeconomic cost-effectiveness analysis. Results According to the evaluation by cost-effectiveness analysis, C was the best scheme. Conclusion The cost-effectiveness analysis is very important in optimizing therapeutic scheme, guiding rational drug use and increasing economic effectiveness.
Objective To evaluate the economic effectiveness of 3 therapeutic schemes for lower respiratory tract infection in the elderly. Methods Three schemes of the treatment of lower respiratory tract infection in the elderly from literatrure cefoperazone/sulbactam(A), imipenem/cilastatin(B), ceftazidime(C) were selected. Data was evaluated using the pharmacoeconomic cost-effectiveness analysis. Results According to the evaluation by cost-effectiveness analysis, C was the best scheme. Conclusion The cost-effectiveness analysis is very important in optimizing therapeutic scheme, guiding rational drug use and increasing economic effectiveness.
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