Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

Lu ying, Ji Xiao-xin, Gao Shen, Liu Yi-qing. Studies of lidocaine-lecithin microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 141-143,155.
Citation: Lu ying, Ji Xiao-xin, Gao Shen, Liu Yi-qing. Studies of lidocaine-lecithin microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 141-143,155.

Studies of lidocaine-lecithin microemulsion

  • Received Date: 2003-03-03
  • Objective To study the formation of transdermal delivery system of lidocaine with lecithin microemulsions as delivery system.Methods Area of water in oil microemulsions was investigated through pseudo ternary phase diagrams. Viscosity of microemulsions were measured to select the the right formulation using orthogonal test method. The content of hydrochloride lidocaine in microemulsions was measured by spectrophotometric. Results Nature of cosurfactant and K m showed predominant influence on the area of microemulsions, area of microemulsions in propanol and iso propanol system were larger. The area of microemulsions was larger in low purity lecithin system. Cosurfactant showed predominant influence on the viscosity of the microemulsion. Content of lidocaine was measured at 262nm, the standard curve was linear in the range of 0.02~0.5mg/mL, the average recovery was (100.17±0.16)%, the within day and between day precision of determination of lidocaine was 0.0137±0.0121, 0.0119±0.0115. Conclusion Choosing mixed surfactant will help the formation of microemulsion. Nature and potent of alcohol have very important effect on selection of the formulation of lidocaine transdermal microemulsions.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2375) PDF downloads(1080) Cited by()

Related
Proportional views

Studies of lidocaine-lecithin microemulsion

Abstract: Objective To study the formation of transdermal delivery system of lidocaine with lecithin microemulsions as delivery system.Methods Area of water in oil microemulsions was investigated through pseudo ternary phase diagrams. Viscosity of microemulsions were measured to select the the right formulation using orthogonal test method. The content of hydrochloride lidocaine in microemulsions was measured by spectrophotometric. Results Nature of cosurfactant and K m showed predominant influence on the area of microemulsions, area of microemulsions in propanol and iso propanol system were larger. The area of microemulsions was larger in low purity lecithin system. Cosurfactant showed predominant influence on the viscosity of the microemulsion. Content of lidocaine was measured at 262nm, the standard curve was linear in the range of 0.02~0.5mg/mL, the average recovery was (100.17±0.16)%, the within day and between day precision of determination of lidocaine was 0.0137±0.0121, 0.0119±0.0115. Conclusion Choosing mixed surfactant will help the formation of microemulsion. Nature and potent of alcohol have very important effect on selection of the formulation of lidocaine transdermal microemulsions.

Lu ying, Ji Xiao-xin, Gao Shen, Liu Yi-qing. Studies of lidocaine-lecithin microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 141-143,155.
Citation: Lu ying, Ji Xiao-xin, Gao Shen, Liu Yi-qing. Studies of lidocaine-lecithin microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 141-143,155.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return