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LIU Meng, LI Zhi-mei. Determination of acetaminophen in compound paracetamol and zinc gluconate tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 167-168.
Citation: LIU Meng, LI Zhi-mei. Determination of acetaminophen in compound paracetamol and zinc gluconate tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 167-168.

Determination of acetaminophen in compound paracetamol and zinc gluconate tablets by HPLC

  • Received Date: 2004-02-24
  • Objective To establish a HPLC method for determination of acetaminophen in compound paracetmol and zinc gluconate tablets. Methods Alltech-C18 (4.6×250mm,5μm)column was used and the mobile phase consisted of methanol and water (20:80). It was detected at 246nm. Results Linearity was obtained in the concentration rage of 4~60μg/mL, A=-13496.960 9+78302.6211C(r=0.9999).The average recovery was 99.83%,RSD=0.93%(n=6). Conclusion The method provide an accurate and sensitive way for the determination of acetaminophen in compound paracetmol and zinc gluconate tablets by HPLC.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of acetaminophen in compound paracetamol and zinc gluconate tablets by HPLC

Abstract: Objective To establish a HPLC method for determination of acetaminophen in compound paracetmol and zinc gluconate tablets. Methods Alltech-C18 (4.6×250mm,5μm)column was used and the mobile phase consisted of methanol and water (20:80). It was detected at 246nm. Results Linearity was obtained in the concentration rage of 4~60μg/mL, A=-13496.960 9+78302.6211C(r=0.9999).The average recovery was 99.83%,RSD=0.93%(n=6). Conclusion The method provide an accurate and sensitive way for the determination of acetaminophen in compound paracetmol and zinc gluconate tablets by HPLC.

LIU Meng, LI Zhi-mei. Determination of acetaminophen in compound paracetamol and zinc gluconate tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 167-168.
Citation: LIU Meng, LI Zhi-mei. Determination of acetaminophen in compound paracetamol and zinc gluconate tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (3): 167-168.

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