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CHEN Yuan-jun, ZHOU Jin-sheng, LU Yu-lan, DING Chuan, HU Xiao-tian, LIAN Jing-long. Determination of two components in compound hydrocortisone nasal drops by new vierordt method[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 331-333.
Citation: CHEN Yuan-jun, ZHOU Jin-sheng, LU Yu-lan, DING Chuan, HU Xiao-tian, LIAN Jing-long. Determination of two components in compound hydrocortisone nasal drops by new vierordt method[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 331-333.

Determination of two components in compound hydrocortisone nasal drops by new vierordt method

  • Received Date: 2004-02-06
  • Objective To determinate two components of hydrocortisone acetate and chlorphenamine maleate in compound hydro-cortisone nasal drops.Methods The components were determinated directly by new Vierordt mothod without separation.The detection wavelengths were 242.5nm and 261.5nm.The blank reference was ethanol absolute.Results The result showed good linear relationship between the concentration and the peak area ratio of the two components.The respective correlation coefficients of hydrocortisone and chlorphenamine maleate were 0.9998 in the range of 1.7754μg/mL to 17.754μg/mL and 0.9997 in the range of 2.656μg/mL to 26.56μg/mL.Average recovery of hydrocortisone and chlorphenamine maleate were 99.6% with RSD 0.8% and 99.7% with RSD 0.6%,respectively.The result of multiplying a by β was less than 0.5.The ratios of A261.5a+b to βA242.5a+b, and A242.5a+b to αA261.5a+b were both more than 1.2.According to new Vierordt method, the result is acceptable.Conclusion The mothod is simple, rapid and repeat able.The interference of the two components on each other can be eliminated and the result is reliable.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of two components in compound hydrocortisone nasal drops by new vierordt method

Abstract: Objective To determinate two components of hydrocortisone acetate and chlorphenamine maleate in compound hydro-cortisone nasal drops.Methods The components were determinated directly by new Vierordt mothod without separation.The detection wavelengths were 242.5nm and 261.5nm.The blank reference was ethanol absolute.Results The result showed good linear relationship between the concentration and the peak area ratio of the two components.The respective correlation coefficients of hydrocortisone and chlorphenamine maleate were 0.9998 in the range of 1.7754μg/mL to 17.754μg/mL and 0.9997 in the range of 2.656μg/mL to 26.56μg/mL.Average recovery of hydrocortisone and chlorphenamine maleate were 99.6% with RSD 0.8% and 99.7% with RSD 0.6%,respectively.The result of multiplying a by β was less than 0.5.The ratios of A261.5a+b to βA242.5a+b, and A242.5a+b to αA261.5a+b were both more than 1.2.According to new Vierordt method, the result is acceptable.Conclusion The mothod is simple, rapid and repeat able.The interference of the two components on each other can be eliminated and the result is reliable.

CHEN Yuan-jun, ZHOU Jin-sheng, LU Yu-lan, DING Chuan, HU Xiao-tian, LIAN Jing-long. Determination of two components in compound hydrocortisone nasal drops by new vierordt method[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 331-333.
Citation: CHEN Yuan-jun, ZHOU Jin-sheng, LU Yu-lan, DING Chuan, HU Xiao-tian, LIAN Jing-long. Determination of two components in compound hydrocortisone nasal drops by new vierordt method[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 331-333.

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