2004 Vol. 22, No. 6
Display Method:
2004, (6): 324-326.
Abstract:
β2-receptor stimulating tulobuterol for prolonged relief of obstructive disorders of airway, such as bronchial asthma, chronic bronchitis, and bronchitis with asthma.This review relates to preparations for percutaneously administering and provides the reference for large-scale production and clinical use.
β2-receptor stimulating tulobuterol for prolonged relief of obstructive disorders of airway, such as bronchial asthma, chronic bronchitis, and bronchitis with asthma.This review relates to preparations for percutaneously administering and provides the reference for large-scale production and clinical use.
2004, (6): 331-333.
Abstract:
Objective To determinate two components of hydrocortisone acetate and chlorphenamine maleate in compound hydro-cortisone nasal drops.Methods The components were determinated directly by new Vierordt mothod without separation.The detection wavelengths were 242.5nm and 261.5nm.The blank reference was ethanol absolute.Results The result showed good linear relationship between the concentration and the peak area ratio of the two components.The respective correlation coefficients of hydrocortisone and chlorphenamine maleate were 0.9998 in the range of 1.7754μg/mL to 17.754μg/mL and 0.9997 in the range of 2.656μg/mL to 26.56μg/mL.Average recovery of hydrocortisone and chlorphenamine maleate were 99.6% with RSD 0.8% and 99.7% with RSD 0.6%,respectively.The result of multiplying a by β was less than 0.5.The ratios of A261.5a+b to βA242.5a+b, and A242.5a+b to αA261.5a+b were both more than 1.2.According to new Vierordt method, the result is acceptable.Conclusion The mothod is simple, rapid and repeat able.The interference of the two components on each other can be eliminated and the result is reliable.
Objective To determinate two components of hydrocortisone acetate and chlorphenamine maleate in compound hydro-cortisone nasal drops.Methods The components were determinated directly by new Vierordt mothod without separation.The detection wavelengths were 242.5nm and 261.5nm.The blank reference was ethanol absolute.Results The result showed good linear relationship between the concentration and the peak area ratio of the two components.The respective correlation coefficients of hydrocortisone and chlorphenamine maleate were 0.9998 in the range of 1.7754μg/mL to 17.754μg/mL and 0.9997 in the range of 2.656μg/mL to 26.56μg/mL.Average recovery of hydrocortisone and chlorphenamine maleate were 99.6% with RSD 0.8% and 99.7% with RSD 0.6%,respectively.The result of multiplying a by β was less than 0.5.The ratios of A261.5a+b to βA242.5a+b, and A242.5a+b to αA261.5a+b were both more than 1.2.According to new Vierordt method, the result is acceptable.Conclusion The mothod is simple, rapid and repeat able.The interference of the two components on each other can be eliminated and the result is reliable.
2004, (6): 333-335.
Abstract:
Objective To establish a method for determination of the content of sulfadiazine in compound nasal ointment.Methods RP-HPLC was adopted with Shim-pack VP-ODS(250L×4.6) column as analytical column, methanol-water-aceti-cacid (40:60:0.1) as mobile phase.The detection wavelength was 270nm.The flow rate was 0.6mL/min. Results The linear ranges of sulfadiazine were 11.26-123.82μg/mL,Y = 144647X-41558,r =0.9999,the average recovery was (100.2±1.5)%,RSD was 1.4%(n=6).Conclusion The method is simple, rapid, accurate and suitable for the determination of sulfadiazine in compound nasal ointment.
Objective To establish a method for determination of the content of sulfadiazine in compound nasal ointment.Methods RP-HPLC was adopted with Shim-pack VP-ODS(250L×4.6) column as analytical column, methanol-water-aceti-cacid (40:60:0.1) as mobile phase.The detection wavelength was 270nm.The flow rate was 0.6mL/min. Results The linear ranges of sulfadiazine were 11.26-123.82μg/mL,Y = 144647X-41558,r =0.9999,the average recovery was (100.2±1.5)%,RSD was 1.4%(n=6).Conclusion The method is simple, rapid, accurate and suitable for the determination of sulfadiazine in compound nasal ointment.
2004, (6): 338-340.
Abstract:
Objective To evaluate the analgesic effect, the life quality and toxic action of rectal administration of morphine sulfate controlled-release tablets (MST) in patients with oral administration.Methods 41 patients with cancer pain and with nausea, vomiting, obstruction and dysphagia were treated with rectal administration of MST, 12h a cycle.For comparision, 32 patients were treated with oral administration of MST, 12h a cycle.Results The total effective rate of the group of rectal administration was 97.56%.Incidence of the toxic action was 19.52%.Karnofsky was advanced from(45.24 ± 8.21) to (66.22 ±11.6) ;The total effective rate of the oral morphine group was 96.87%.Incidence of the toxic action was 56.24%.Karnofsky was advanced from (47.81 ± 12.11) to (66.72 ± 10.36).Analgesic effect and the life quality showed statistical significant difference between the two groups (P > 0.05).Toxicity showed statistical difference between the two groups (P < 0.01).Conclusion Rectal administration of MST for treatment of cancer pain was as effective as oral administration of MST.But the side effects was mild.The rectal administration of MST is fit especially for the patients, that oral administration is not available.
Objective To evaluate the analgesic effect, the life quality and toxic action of rectal administration of morphine sulfate controlled-release tablets (MST) in patients with oral administration.Methods 41 patients with cancer pain and with nausea, vomiting, obstruction and dysphagia were treated with rectal administration of MST, 12h a cycle.For comparision, 32 patients were treated with oral administration of MST, 12h a cycle.Results The total effective rate of the group of rectal administration was 97.56%.Incidence of the toxic action was 19.52%.Karnofsky was advanced from(45.24 ± 8.21) to (66.22 ±11.6) ;The total effective rate of the oral morphine group was 96.87%.Incidence of the toxic action was 56.24%.Karnofsky was advanced from (47.81 ± 12.11) to (66.72 ± 10.36).Analgesic effect and the life quality showed statistical significant difference between the two groups (P > 0.05).Toxicity showed statistical difference between the two groups (P < 0.01).Conclusion Rectal administration of MST for treatment of cancer pain was as effective as oral administration of MST.But the side effects was mild.The rectal administration of MST is fit especially for the patients, that oral administration is not available.
2004, (6): 342-343.
Abstract:
Objective To observe the effecacy and safety of acyclovir combined with UV-anion spray in the treatment of herpes zoster. Methods The patients were divided into 2 groups.ACV combined with UV-anion spray was therapy group.The single use ACV was control group.Results The effective rate of therapy group and the control group were 88.00%, 67.39%,respectively.There is obvious difference between the two groups (P <0.01).The aeesodyne effect of the therapy group was better than that of the control group significantly (P <0.01).Conclusion UV-anion spray combined AGV in the treatment of herpes zoster following is a safe, effective method.
Objective To observe the effecacy and safety of acyclovir combined with UV-anion spray in the treatment of herpes zoster. Methods The patients were divided into 2 groups.ACV combined with UV-anion spray was therapy group.The single use ACV was control group.Results The effective rate of therapy group and the control group were 88.00%, 67.39%,respectively.There is obvious difference between the two groups (P <0.01).The aeesodyne effect of the therapy group was better than that of the control group significantly (P <0.01).Conclusion UV-anion spray combined AGV in the treatment of herpes zoster following is a safe, effective method.
2004, (6): 348-349.
Abstract:
Objective To observe the application of low-dose ropivacaine for cervical plexus anesthetic in the operation of collarbone fracture. Method The cervical plexus were selected to block anesthetic and punctured at c4 transverse.7mL ropivicaine (0.25%) was given to deep plexus and 15mL to shallow plexus comparing with the same way by mixture solution of tetracaine (0.15%) and lidocaine (1.00%). Result The anesthetic effective rate of observation group and controlled group were 95.6% and 95.4% respectively and no significant difference between them.For the side effect, there had a significant difference between the two groups.The side effect of observation group was less than the controlled group.(P<0.05) Conclusion The anesthetic effect of low-dose ropivaciane was good and had little side effect.It is a good way for the cervical plexus anesthetic.
Objective To observe the application of low-dose ropivacaine for cervical plexus anesthetic in the operation of collarbone fracture. Method The cervical plexus were selected to block anesthetic and punctured at c4 transverse.7mL ropivicaine (0.25%) was given to deep plexus and 15mL to shallow plexus comparing with the same way by mixture solution of tetracaine (0.15%) and lidocaine (1.00%). Result The anesthetic effective rate of observation group and controlled group were 95.6% and 95.4% respectively and no significant difference between them.For the side effect, there had a significant difference between the two groups.The side effect of observation group was less than the controlled group.(P<0.05) Conclusion The anesthetic effect of low-dose ropivaciane was good and had little side effect.It is a good way for the cervical plexus anesthetic.
2004, (6): 350-352.
Abstract:
Objective To prepare aciclovir eye ointment and establish a quality control standard. Methods The eye ointment was prepared with yellow vaseline, wool fat and anhydrous.RP-HPLC was applied to quantitative analysis. Results The average recovery rate of aciclovir was 98.47%,RSD was 1.20%(n=5).Conclusion The preparation of aciclovir eye ointment was simple, its property was stable and its quality can be controlled for the clinical use.The determination of content was accurate and rapid by RP-HPLC.
Objective To prepare aciclovir eye ointment and establish a quality control standard. Methods The eye ointment was prepared with yellow vaseline, wool fat and anhydrous.RP-HPLC was applied to quantitative analysis. Results The average recovery rate of aciclovir was 98.47%,RSD was 1.20%(n=5).Conclusion The preparation of aciclovir eye ointment was simple, its property was stable and its quality can be controlled for the clinical use.The determination of content was accurate and rapid by RP-HPLC.
2004, (6): 352-354.
Abstract:
Objective To study the relationship between packaging material for pharmaceutical products and the safety of drug use. Methods The relevant papers were analyzed combined with the actual situation in China, Results The quality of packaging material might do certain harm to human body and also have various negative effects on the pharmaceutical products' quality.Conclusion The selection of appropriate packaging materials should comply with the product's pharmacological nature; and manufacturing enterprise should follow specialized standards to cope with different drugs.
Objective To study the relationship between packaging material for pharmaceutical products and the safety of drug use. Methods The relevant papers were analyzed combined with the actual situation in China, Results The quality of packaging material might do certain harm to human body and also have various negative effects on the pharmaceutical products' quality.Conclusion The selection of appropriate packaging materials should comply with the product's pharmacological nature; and manufacturing enterprise should follow specialized standards to cope with different drugs.
2004, (6): 357-357.
Abstract:
Objective To establish a method of determination of contents in Hueizhilin ointment. Methods HPLC was used with C18 column as stationary phase and methanol-sodium dihydrogen phosphate (40:60) as mobile phase.The detection wavelength was 254nm.Results The calibration curve is linear between 40.0～200.0μg/mL of resorcinol salicylic acid and benzoic acid.The average recorery was 98.1%, 97.9%,97.7% with RSD of 1.88%,1.82%,1.46%.Conclusion The method is reliable, accurate and can be used for the determination of the contents of Hueizhilin ointment.
Objective To establish a method of determination of contents in Hueizhilin ointment. Methods HPLC was used with C18 column as stationary phase and methanol-sodium dihydrogen phosphate (40:60) as mobile phase.The detection wavelength was 254nm.Results The calibration curve is linear between 40.0～200.0μg/mL of resorcinol salicylic acid and benzoic acid.The average recorery was 98.1%, 97.9%,97.7% with RSD of 1.88%,1.82%,1.46%.Conclusion The method is reliable, accurate and can be used for the determination of the contents of Hueizhilin ointment.
2004, (6): 374-376.
Abstract:
Objective To evaluate the economic effectiveness of different drug therapeutic schemes for the same disease.Methods Using pharmacoeconomical cost-effectiveness analysis,four therapeutic schemes for chronic hepatitis B (A-alkoloids sophora injection, B-lamivudine + thymosin, C-interferon, D-lamivudine) were compared.Results The effective rates of four groups were 74.14%, 91.25%,82.86% and 83.33% respectively; The adverse drug reaction rates were 12.07%,8.75%,38.57% and 1.39%.And the cos-effectiveness ratios were respectively 88.83,134.89,174.11 and 91.03.Conclusion Schemes D are the best one.
Objective To evaluate the economic effectiveness of different drug therapeutic schemes for the same disease.Methods Using pharmacoeconomical cost-effectiveness analysis,four therapeutic schemes for chronic hepatitis B (A-alkoloids sophora injection, B-lamivudine + thymosin, C-interferon, D-lamivudine) were compared.Results The effective rates of four groups were 74.14%, 91.25%,82.86% and 83.33% respectively; The adverse drug reaction rates were 12.07%,8.75%,38.57% and 1.39%.And the cos-effectiveness ratios were respectively 88.83,134.89,174.11 and 91.03.Conclusion Schemes D are the best one.
2004, (6): 376-377,367.
Abstract:
Objective To evaluate the economic effects of azithromycin, minoeycline and fleroxacin in treatment of male non-gonococcal urethritis.Methods The evaluation was conducted by pharmacoeconomical cost-effectiveness analysis.Results The cure rate (89.29%) of azithromycin was the highest, and its additional cost was the lowest when the cure rate reached to 100%.Conclusion The best scheme was azithromycin in treatment of male non-gonococcal urethritis.
Objective To evaluate the economic effects of azithromycin, minoeycline and fleroxacin in treatment of male non-gonococcal urethritis.Methods The evaluation was conducted by pharmacoeconomical cost-effectiveness analysis.Results The cure rate (89.29%) of azithromycin was the highest, and its additional cost was the lowest when the cure rate reached to 100%.Conclusion The best scheme was azithromycin in treatment of male non-gonococcal urethritis.
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