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WU Hong-wen, WU Min. Determination of sulfadiazine in compound nasal ointment by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 333-335.
Citation: WU Hong-wen, WU Min. Determination of sulfadiazine in compound nasal ointment by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 333-335.

Determination of sulfadiazine in compound nasal ointment by RP-HPLC

  • Received Date: 2003-12-22
  • Objective To establish a method for determination of the content of sulfadiazine in compound nasal ointment.Methods RP-HPLC was adopted with Shim-pack VP-ODS(250L×4.6) column as analytical column, methanol-water-aceti-cacid (40:60:0.1) as mobile phase.The detection wavelength was 270nm.The flow rate was 0.6mL/min. Results The linear ranges of sulfadiazine were 11.26-123.82μg/mL,Y = 144647X-41558,r =0.9999,the average recovery was (100.2±1.5)%,RSD was 1.4%(n=6).Conclusion The method is simple, rapid, accurate and suitable for the determination of sulfadiazine in compound nasal ointment.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of sulfadiazine in compound nasal ointment by RP-HPLC

Abstract: Objective To establish a method for determination of the content of sulfadiazine in compound nasal ointment.Methods RP-HPLC was adopted with Shim-pack VP-ODS(250L×4.6) column as analytical column, methanol-water-aceti-cacid (40:60:0.1) as mobile phase.The detection wavelength was 270nm.The flow rate was 0.6mL/min. Results The linear ranges of sulfadiazine were 11.26-123.82μg/mL,Y = 144647X-41558,r =0.9999,the average recovery was (100.2±1.5)%,RSD was 1.4%(n=6).Conclusion The method is simple, rapid, accurate and suitable for the determination of sulfadiazine in compound nasal ointment.

WU Hong-wen, WU Min. Determination of sulfadiazine in compound nasal ointment by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 333-335.
Citation: WU Hong-wen, WU Min. Determination of sulfadiazine in compound nasal ointment by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 333-335.

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