Determination of sulfadiazine in compound nasal ointment by RP-HPLC
- Received Date: 2003-12-22
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Key words:
- RP-HPLC /
- sulfadiazine /
- compound nasal ointment
Abstract: Objective To establish a method for determination of the content of sulfadiazine in compound nasal ointment.Methods RP-HPLC was adopted with Shim-pack VP-ODS(250L×4.6) column as analytical column, methanol-water-aceti-cacid (40:60:0.1) as mobile phase.The detection wavelength was 270nm.The flow rate was 0.6mL/min. Results The linear ranges of sulfadiazine were 11.26-123.82μg/mL,Y = 144647X-41558,r =0.9999,the average recovery was (100.2±1.5)%,RSD was 1.4%(n=6).Conclusion The method is simple, rapid, accurate and suitable for the determination of sulfadiazine in compound nasal ointment.
Citation: | WU Hong-wen, WU Min. Determination of sulfadiazine in compound nasal ointment by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 333-335. |