Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

SHI Lu, YAN Xiao-wei, CHEN Jun-gang. Clinial observation of rectal administration of morphine sulfate controlled-re-lease tablets for treatment of cancer pain[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 338-340.
Citation: SHI Lu, YAN Xiao-wei, CHEN Jun-gang. Clinial observation of rectal administration of morphine sulfate controlled-re-lease tablets for treatment of cancer pain[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 338-340.

Clinial observation of rectal administration of morphine sulfate controlled-re-lease tablets for treatment of cancer pain

  • Received Date: 2004-06-29
  • Objective To evaluate the analgesic effect, the life quality and toxic action of rectal administration of morphine sulfate controlled-release tablets (MST) in patients with oral administration.Methods 41 patients with cancer pain and with nausea, vomiting, obstruction and dysphagia were treated with rectal administration of MST, 12h a cycle.For comparision, 32 patients were treated with oral administration of MST, 12h a cycle.Results The total effective rate of the group of rectal administration was 97.56%.Incidence of the toxic action was 19.52%.Karnofsky was advanced from(45.24 ± 8.21) to (66.22 ±11.6) ;The total effective rate of the oral morphine group was 96.87%.Incidence of the toxic action was 56.24%.Karnofsky was advanced from (47.81 ± 12.11) to (66.72 ± 10.36).Analgesic effect and the life quality showed statistical significant difference between the two groups (P > 0.05).Toxicity showed statistical difference between the two groups (P < 0.01).Conclusion Rectal administration of MST for treatment of cancer pain was as effective as oral administration of MST.But the side effects was mild.The rectal administration of MST is fit especially for the patients, that oral administration is not available.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2562) PDF downloads(546) Cited by()

Related
Proportional views

Clinial observation of rectal administration of morphine sulfate controlled-re-lease tablets for treatment of cancer pain

Abstract: Objective To evaluate the analgesic effect, the life quality and toxic action of rectal administration of morphine sulfate controlled-release tablets (MST) in patients with oral administration.Methods 41 patients with cancer pain and with nausea, vomiting, obstruction and dysphagia were treated with rectal administration of MST, 12h a cycle.For comparision, 32 patients were treated with oral administration of MST, 12h a cycle.Results The total effective rate of the group of rectal administration was 97.56%.Incidence of the toxic action was 19.52%.Karnofsky was advanced from(45.24 ± 8.21) to (66.22 ±11.6) ;The total effective rate of the oral morphine group was 96.87%.Incidence of the toxic action was 56.24%.Karnofsky was advanced from (47.81 ± 12.11) to (66.72 ± 10.36).Analgesic effect and the life quality showed statistical significant difference between the two groups (P > 0.05).Toxicity showed statistical difference between the two groups (P < 0.01).Conclusion Rectal administration of MST for treatment of cancer pain was as effective as oral administration of MST.But the side effects was mild.The rectal administration of MST is fit especially for the patients, that oral administration is not available.

SHI Lu, YAN Xiao-wei, CHEN Jun-gang. Clinial observation of rectal administration of morphine sulfate controlled-re-lease tablets for treatment of cancer pain[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 338-340.
Citation: SHI Lu, YAN Xiao-wei, CHEN Jun-gang. Clinial observation of rectal administration of morphine sulfate controlled-re-lease tablets for treatment of cancer pain[J]. Journal of Pharmaceutical Practice and Service, 2004, (6): 338-340.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return