Study on liver metabolism function in adult female at different ages

Key words: 
• adult female /
• caffeine clearance /
• liver metabolism function

Abstract: Objective To investigate the difference of liver metabolism function in healthy adult female at different ages. Methods The saliva caffeine clearance(SCL) was determined by RP-HPLC method in 49 healthy adult females aged 18～34 years, 46 aged 35～50 and 18 aged 51～60 years. Results The SCL of 18～34 year group was normal. There was significant difference between 18～34 year group and others(P<0.001), significant difference was also found between 35～50 year group and 51～60 year group(P<0.001). Conclusion The SCL in female decreased with age and the liver metabolism function become lower.