Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 23 Issue 6
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2005  >  (6): 345-347,361

GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
Citation: GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
shu

The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance

  • 1.

    Departmemt of Pharmacy, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233

  • 2.

    Departmemt of Pharmacy, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233;School of Pharmacy, Second Military Medical University, Shanghai 200433

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433

  • Received Date: 2005-09-14
  • Objective To observe the antidepressant activity of the active components from Hypericum sampsonii Hance. Methods The total flavonoids product from H. sampsonii were examined by Forced Swimming Test(FST) and Reserpine Reversal Test(RRT) in mice. Results Three doses(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) of the total flavonoids product(contains 68.30% total flavonoids) from H. sampsonii were examined by FST in mice, which reduced duration immobility with dose response by 5.97%, 41.85% and 45.96% respectively. In addition, the different doses of the total flavonoids(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) were examined by RRT, which induced hypothermia by low dose reserpine(5mg/kg, i.p.). In this study, the three doses of total flavonoids reversed hypothermia to some extent but with no dose response relationship. Conclusion The flavonoids compounds are the antidepressant components from H. sampsonii Hance.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2322) PDF downloads(432) Cited by()

Related
Proportional views

The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance

  • 1. Departmemt of Pharmacy, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233
  • 2. Departmemt of Pharmacy, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233;School of Pharmacy, Second Military Medical University, Shanghai 200433
  • 3. School of Pharmacy, Second Military Medical University, Shanghai 200433
  • Received Date: 2005-09-14

Abstract: Objective To observe the antidepressant activity of the active components from Hypericum sampsonii Hance. Methods The total flavonoids product from H. sampsonii were examined by Forced Swimming Test(FST) and Reserpine Reversal Test(RRT) in mice. Results Three doses(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) of the total flavonoids product(contains 68.30% total flavonoids) from H. sampsonii were examined by FST in mice, which reduced duration immobility with dose response by 5.97%, 41.85% and 45.96% respectively. In addition, the different doses of the total flavonoids(150mg/(kg·d), 300mg/(kg·d) and 600mg/(kg·d), i.g.) were examined by RRT, which induced hypothermia by low dose reserpine(5mg/kg, i.p.). In this study, the three doses of total flavonoids reversed hypothermia to some extent but with no dose response relationship. Conclusion The flavonoids compounds are the antidepressant components from H. sampsonii Hance.

GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
Citation: GUO Cheng, ZHENG Qing-ming, ZHENG Han-chen. The Study of antidepressant activity of the total flavonoids product from Hypericum sampsonii Hance[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 345-347,361.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return