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Volume 23 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2005  >  (6): 359-361

HU Dao-De, Tian Feng, Liou Gao-Lin. Study on the preparation and quality control of compound dexamethasone liniment[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 359-361.
Citation: HU Dao-De, Tian Feng, Liou Gao-Lin. Study on the preparation and quality control of compound dexamethasone liniment[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 359-361.
shu

Study on the preparation and quality control of compound dexamethasone liniment

  • Department of Pharmacy, First Affiliated People's Hospital Shanghai Jiaotong University, Shanghai 200080, China

  • Received Date: 2005-10-18
  • Objective To investigate the preparation and quality control of compound dexamethasone liniment. Methods The compound dexamethasone liniment was prepared by taking alcohol as a solvent. The content of dexamethasone acetate in the formulation was determined by ultra-violet spectrophotometry. Results The liniment was homogenous and transparent. The calibration curve of dexamethasone acetate was linear over the concentration range of 7.5 to 17.5mg/L. The regression equation was:C=28.5299.4+0.05125, r=0.9999(n=5,P<0.01), the average recoveries of high, medium and low concentrations for dexamethasone acetate were 102.55% , 101.40% and 102.08%, respectively. The mean relative standard deviations(RSD) were 0.69%, 1.35% and 1.16%, respectively. Conclusion The formulation is simple and reasonable. The method of quality control is rapid and accurate.
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Study on the preparation and quality control of compound dexamethasone liniment

  • Department of Pharmacy, First Affiliated People's Hospital Shanghai Jiaotong University, Shanghai 200080, China
  • Received Date: 2005-10-18

Abstract: Objective To investigate the preparation and quality control of compound dexamethasone liniment. Methods The compound dexamethasone liniment was prepared by taking alcohol as a solvent. The content of dexamethasone acetate in the formulation was determined by ultra-violet spectrophotometry. Results The liniment was homogenous and transparent. The calibration curve of dexamethasone acetate was linear over the concentration range of 7.5 to 17.5mg/L. The regression equation was:C=28.5299.4+0.05125, r=0.9999(n=5,P<0.01), the average recoveries of high, medium and low concentrations for dexamethasone acetate were 102.55% , 101.40% and 102.08%, respectively. The mean relative standard deviations(RSD) were 0.69%, 1.35% and 1.16%, respectively. Conclusion The formulation is simple and reasonable. The method of quality control is rapid and accurate.

HU Dao-De, Tian Feng, Liou Gao-Lin. Study on the preparation and quality control of compound dexamethasone liniment[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 359-361.
Citation: HU Dao-De, Tian Feng, Liou Gao-Lin. Study on the preparation and quality control of compound dexamethasone liniment[J]. Journal of Pharmaceutical Practice and Service, 2005, (6): 359-361.
shu

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