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Volume 24 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (5): 264-267

QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
Citation: QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
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Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages

  • 1.

    Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2005-09-05
  • Objective: To study the effects of four flavonoids （fisetin, quercetin, apigenin, and phloretin） on production and ac-tions of fibrogenic cytokines. Methods: Mouse peritoneal macrophages were primed with calcimycin 10-6mol/L for 8h then elicited by lipopolysaccharides （LPS） 100g/L for 6h to induce fibrogenic cytokines.Proliferative and collagen stimulating activity in the macro-phage culture supernatants was determined by crystal violet staining assay and [3H]-proline incorporation assay using rat hepatic stel-late HSC-T6 cell.Transforming growth factorβ（TGFβ） activity was measured by [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell. Results: Fisetin, quercetin, apigenin, and phloretin （12.5～50μmol/L） concentration-dependently inhibit LPS-induced collagen stimulating activities and TGFβproduction whereas they did not inhibit proliferative activities released by macro-phages. Conclusion: The four flavonoids reducted fibrogenic cytokines production and blockade of their actions on hepatic stellate cells.
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Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages

  • 1. Department of Pharmacy, Fuzhou General Hospital, PLA Nanjing Military Area Command, Fuzhou 350001
  • 2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2005-09-05

Abstract: Objective: To study the effects of four flavonoids （fisetin, quercetin, apigenin, and phloretin） on production and ac-tions of fibrogenic cytokines. Methods: Mouse peritoneal macrophages were primed with calcimycin 10-6mol/L for 8h then elicited by lipopolysaccharides （LPS） 100g/L for 6h to induce fibrogenic cytokines.Proliferative and collagen stimulating activity in the macro-phage culture supernatants was determined by crystal violet staining assay and [3H]-proline incorporation assay using rat hepatic stel-late HSC-T6 cell.Transforming growth factorβ（TGFβ） activity was measured by [3H]-thymidine incorporation assay using Mv-1-Lu mink lung epithelial cell. Results: Fisetin, quercetin, apigenin, and phloretin （12.5～50μmol/L） concentration-dependently inhibit LPS-induced collagen stimulating activities and TGFβproduction whereas they did not inhibit proliferative activities released by macro-phages. Conclusion: The four flavonoids reducted fibrogenic cytokines production and blockade of their actions on hepatic stellate cells.

QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
Citation: QI Li-hong, Liu ye, Xiao Zhen yu, Wang Shuo-feng, ZHANG min, ZHANG Jun-ping. Inhibitory effects of four flavonoids on production and actions of fibrogenic cytokines released by mouse peritoneal macrophages[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 264-267.
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