Separation of Enantiomer of Amlodipine by CE and HPLC

HU Jian-guo; LE Jian; LIU Chang-hai; CHEN Gui-Liang

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

x Close Forever Close

PDF
Cite
Share

facebook

twitter

google

linkedin

Volume 24 Issue 5

Turn off MathJax

Article Contents

Article Navigation > Journal of Pharmaceutical Practice and Service > 2006 > (5): 289-291

HU Jian-guo, LE Jian, LIU Chang-hai, CHEN Gui-Liang. Separation of Enantiomer of Amlodipine by CE and HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 289-291.

Citation:

HU Jian-guo, LE Jian, LIU Chang-hai, CHEN Gui-Liang. Separation of Enantiomer of Amlodipine by CE and HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (5): 289-291.

Separation of Enantiomer of Amlodipine by CE and HPLC

Second Chemistry Department of Shanghai drug control institute, Shanghai 200233, China

Received Date: 2006-01-15

Abstract

Objective: Separation of enantiomer of amlodipine by CE and HPLC. Methods: Different separation conditions such as buffer pH, the concentration of the chiral selector, buffer concentrations, temperature and applied voltage, etc.were studied and op-timized.The separation was finally conducted in 100mM orthophosphoric acid-Tris buffer (pH3.0) with 1.0% (w/w) HP-β-CD.The applied voltage was 16kV and the temperature 15℃. Results: Both CE and HPLC could give enantiomer of amlodipine resolution for adrenaline. Conclusion: The method proved to be specific and accurate
- capillary electrophoresis,
- amlodipine,
- chiral
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(2134) PDF downloads(148) Cited by()

Proportional views