Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.
Citation: ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.

Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC

  • Received Date: 2006-01-25
  • Objective: To establish a method for simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel. Methods: HPLC method was developed.Chromatographic conditions included Hypersil ODS2 C18 column and the mo- bile phase was methanol-0.2% triethylamine(adjust with acetic acid to a pH of 6.9,V:V=75:25).The flow rate was 1.0 mL/ min and the UV detection wavelength was at 239 nm. Results: Ketoconazole had a good linearity(r=0.9999) in the range of 10.08~201.16μg/mL,its average recovery was 99.59%(RSD=0.77%).Clobetasol propionate had a good linearity(r=0.9998) in the range of 0.251~5.02μg/mL,its average recovery was 100.76%(RSD=1.18%). Conclusion: The method was simple, sensitive and accurate for simultaneous determination of the two constituents in compound ketoconazole gel.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2274) PDF downloads(246) Cited by()

Related
Proportional views

Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC

Abstract: Objective: To establish a method for simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel. Methods: HPLC method was developed.Chromatographic conditions included Hypersil ODS2 C18 column and the mo- bile phase was methanol-0.2% triethylamine(adjust with acetic acid to a pH of 6.9,V:V=75:25).The flow rate was 1.0 mL/ min and the UV detection wavelength was at 239 nm. Results: Ketoconazole had a good linearity(r=0.9999) in the range of 10.08~201.16μg/mL,its average recovery was 99.59%(RSD=0.77%).Clobetasol propionate had a good linearity(r=0.9998) in the range of 0.251~5.02μg/mL,its average recovery was 100.76%(RSD=1.18%). Conclusion: The method was simple, sensitive and accurate for simultaneous determination of the two constituents in compound ketoconazole gel.

ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.
Citation: ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return