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Volume 24 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (6): 336-339

ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.
Citation: ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.
shu

Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC

  • 1.

    School of Pharmacy,Fujian Medical University,Fuzhou 350004,China

  • 2.

    Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China

  • Received Date: 2006-01-25
  • Objective: To establish a method for simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel. Methods: HPLC method was developed.Chromatographic conditions included Hypersil ODS2 C18 column and the mo- bile phase was methanol-0.2% triethylamine（adjust with acetic acid to a pH of 6.9,V:V=75:25）.The flow rate was 1.0 mL/ min and the UV detection wavelength was at 239 nm. Results: Ketoconazole had a good linearity（r=0.9999） in the range of 10.08～201.16μg/mL,its average recovery was 99.59%（RSD=0.77%）.Clobetasol propionate had a good linearity（r=0.9998） in the range of 0.251～5.02μg/mL,its average recovery was 100.76%（RSD=1.18%）. Conclusion: The method was simple, sensitive and accurate for simultaneous determination of the two constituents in compound ketoconazole gel.
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Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC

  • 1. School of Pharmacy,Fujian Medical University,Fuzhou 350004,China
  • 2. Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China
  • Received Date: 2006-01-25

Abstract: Objective: To establish a method for simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel. Methods: HPLC method was developed.Chromatographic conditions included Hypersil ODS2 C18 column and the mo- bile phase was methanol-0.2% triethylamine（adjust with acetic acid to a pH of 6.9,V:V=75:25）.The flow rate was 1.0 mL/ min and the UV detection wavelength was at 239 nm. Results: Ketoconazole had a good linearity（r=0.9999） in the range of 10.08～201.16μg/mL,its average recovery was 99.59%（RSD=0.77%）.Clobetasol propionate had a good linearity（r=0.9998） in the range of 0.251～5.02μg/mL,its average recovery was 100.76%（RSD=1.18%）. Conclusion: The method was simple, sensitive and accurate for simultaneous determination of the two constituents in compound ketoconazole gel.

ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.
Citation: ZHANG Qian, SONG Hong-tao, CHEN Ya-ping, KANG Lu-ping. Simultaneous determination of ketoconazole and clobetasol propionate in compound ketoconazole gel by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 336-339.
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