A meta-analysis of treatment of bacterial infections with double-blind randomized clinical study of indigenous gatifloxcin versus levofloxacin
- Received Date: 2006-06-14
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Key words:
- gastifloxacin /
- levofloxacin /
- double-blind randomized /
- bacterial infections /
- meta-analysis
Abstract: Objective: To estimate the efficacy and safety of indigenous gatifloxacin and levofloxacin on bacterial infection. Methods: According to the requirements of Cochrane systematic review,a thorough literature search was performed among Chinese digital Hospital Library(www.chkd.cnki.net) and Chinese Biomedical Literature Disk Database(CBM disk).A meta analysis was per- formed on a total of 2 253 patients involved in 18 papers which met the inclusion criteria. Results: The clinical effective rate of indige- nous gatifloxacin treatment group versus levofloxacin treatment group was found between the two groups( OR 1.42,95% CI 1.03~1.98,Z=2.11 P=0.03) have significant difference.Clinical cure rates、corresponding bacterial eradication rates and adverse reac- tion rates have no significant difference. Conclusions: Indigenous gatifloxacin treatment bacterial infection effectivenessis higher than levofloxacin.
Citation: | ZHANG Mei-he, HUANG Cheng-hua, DING Xiao-hu, SHEN Xiao-qin, HAN Zhu-jun. A meta-analysis of treatment of bacterial infections with double-blind randomized clinical study of indigenous gatifloxcin versus levofloxacin[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 346-351. |