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Volume 24 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (6): 357-359

YU Ai-he, ZHANG Lan-hua, YANG Yu-ying. Determination of strychnine and brucine in Zhanjin pills by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 357-359.
Citation: YU Ai-he, ZHANG Lan-hua, YANG Yu-ying. Determination of strychnine and brucine in Zhanjin pills by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 357-359.
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Determination of strychnine and brucine in Zhanjin pills by RP-HPLC

  • No.261 Hospital of PLA,Beijing 100094,China

  • Received Date: 2005-11-29
  • Objective: To establish a method for the quality control of Semen Strychni in Zhanjin pills. Methods: An RP-HPLC method for the quantitative determination of strychnine and brucine in Semen Strychni was built.A XTerra TMC18 column（150mm×3.9mm,5μm）was used with a 10mmol/L amonium bicarbonate solution（adjusted to pH 9.5 by ammonia solution）and acetonitrile（75 :25）as the mobile phase.The detective wavelength was 256nm and the column temperature was 35℃.The basifying testing sample was extracted supersonically by chloroform in cold immersion. Results: The linear ranges were 0.432～2.160μg for strychnine and 0.388～1.940μg for brucine.The average recovery and RSD were 100.03% and 2.06% for strychnine,99.41% and 2.41% for bru- cine,respectively. Conclusion: The method was specific,accurate and precise.It could be used for the quality control for Semen Strychni in Zhanjin pills.
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Determination of strychnine and brucine in Zhanjin pills by RP-HPLC

  • No.261 Hospital of PLA,Beijing 100094,China
  • Received Date: 2005-11-29

Abstract: Objective: To establish a method for the quality control of Semen Strychni in Zhanjin pills. Methods: An RP-HPLC method for the quantitative determination of strychnine and brucine in Semen Strychni was built.A XTerra TMC18 column（150mm×3.9mm,5μm）was used with a 10mmol/L amonium bicarbonate solution（adjusted to pH 9.5 by ammonia solution）and acetonitrile（75 :25）as the mobile phase.The detective wavelength was 256nm and the column temperature was 35℃.The basifying testing sample was extracted supersonically by chloroform in cold immersion. Results: The linear ranges were 0.432～2.160μg for strychnine and 0.388～1.940μg for brucine.The average recovery and RSD were 100.03% and 2.06% for strychnine,99.41% and 2.41% for bru- cine,respectively. Conclusion: The method was specific,accurate and precise.It could be used for the quality control for Semen Strychni in Zhanjin pills.

YU Ai-he, ZHANG Lan-hua, YANG Yu-ying. Determination of strychnine and brucine in Zhanjin pills by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 357-359.
Citation: YU Ai-he, ZHANG Lan-hua, YANG Yu-ying. Determination of strychnine and brucine in Zhanjin pills by RP-HPLC[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 357-359.
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