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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (1): 12-15

MAO Jun-qin, LI Tie-jun, QIU Yan, RUI Yao-cheng, GU Zheng-bin. Effects of the iridoid aglycones from Patrinia scabra on colon cancer[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 12-15.
Citation: MAO Jun-qin, LI Tie-jun, QIU Yan, RUI Yao-cheng, GU Zheng-bin. Effects of the iridoid aglycones from Patrinia scabra on colon cancer[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 12-15.
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Effects of the iridoid aglycones from Patrinia scabra on colon cancer

  • 1.

    Department of Pharmacy,No.85 Hospital of PLA,Shanghai 200052,China

  • 2.

    Department of Pharmacology,College of Pharmacy,Second Military Medical University,Shanghai 200433,China

  • 3.

    Department of Phytochemistry,College of Pharmacy,Shanghai 200433,China

  • Received Date: 2006-03-20
  • Objective:To study the effects of the iridoid aglycones from Patrinia scabra on mouse colon cancer cell line C26 in vitro and on transplanting-tumor of mouse colon cancer cell C26. Methods: The effects of the iridoid aglycones from Patrinia scabra(PS-I, BJ3401)on mouse colon cancer cell line C26 were studied by MTF experiment,the transplanting-tumor model of mouse colon cancer was established by hypodermic inoculating the mouse colon cancer cell lines C26 into the FI mice. Results: The iridoid aglycones PS -I and BJ3401 could significantly inhibit proliferation of C26 cell line in a doge-dependent manner,gross iridoid aglycones could sig- nificantly lessen the weight of the transplanting-tumor in mice.Conclusion :The iridoid aglycones from Patrinia scabra have anti-colon carcinoma activity.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Effects of the iridoid aglycones from Patrinia scabra on colon cancer

  • 1. Department of Pharmacy,No.85 Hospital of PLA,Shanghai 200052,China
  • 2. Department of Pharmacology,College of Pharmacy,Second Military Medical University,Shanghai 200433,China
  • 3. Department of Phytochemistry,College of Pharmacy,Shanghai 200433,China
  • Received Date: 2006-03-20

Abstract: Objective:To study the effects of the iridoid aglycones from Patrinia scabra on mouse colon cancer cell line C26 in vitro and on transplanting-tumor of mouse colon cancer cell C26. Methods: The effects of the iridoid aglycones from Patrinia scabra(PS-I, BJ3401)on mouse colon cancer cell line C26 were studied by MTF experiment,the transplanting-tumor model of mouse colon cancer was established by hypodermic inoculating the mouse colon cancer cell lines C26 into the FI mice. Results: The iridoid aglycones PS -I and BJ3401 could significantly inhibit proliferation of C26 cell line in a doge-dependent manner,gross iridoid aglycones could sig- nificantly lessen the weight of the transplanting-tumor in mice.Conclusion :The iridoid aglycones from Patrinia scabra have anti-colon carcinoma activity.

MAO Jun-qin, LI Tie-jun, QIU Yan, RUI Yao-cheng, GU Zheng-bin. Effects of the iridoid aglycones from Patrinia scabra on colon cancer[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 12-15.
Citation: MAO Jun-qin, LI Tie-jun, QIU Yan, RUI Yao-cheng, GU Zheng-bin. Effects of the iridoid aglycones from Patrinia scabra on colon cancer[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 12-15.
shu

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