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2007 Vol. 25, No. 1

Cover
Display Method:
2007, (1): 1-4.
Abstract(1873) PDF (593KB)(168)
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2007, (1): 4-6.
Abstract(1658) PDF (401KB)(500)
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Advances in studies on chemical constituents and pharmacology of Cynanchum atratum
YUAN Ying, ZHANG Wei-dong, LIU Run-hui, HU Xiao-jia, SU Juan, ZHENG Zhao-guang, ZHANG Wei
2007, (1): 10-12.
Abstract(3012) PDF (400KB)(562)
Abstract:
Objections: Review the development on the chemical constituents,pharmacology and clinical application of traditional Chinese medicine Cynanchum atratum Bunge. Methods: Referring the correlated literature at home and abroad. Results: The main constituents were C21 sterodial glycosides,aetherolea,cardiac glycosides and microelements.Cyrtanehum atratum Bunge be used for the treatment of hectic fevers,acute urinary infection and abscesses. Conclusion: Cynanchum atratum Bunge possess wide pharmacol- ogy activies.Further research and development will be significant.
Effects of the iridoid aglycones from Patrinia scabra on colon cancer
MAO Jun-qin, LI Tie-jun, QIU Yan, RUI Yao-cheng, GU Zheng-bin
2007, (1): 12-15.
Abstract(2447) PDF (369KB)(276)
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Objective:To study the effects of the iridoid aglycones from Patrinia scabra on mouse colon cancer cell line C26 in vitro and on transplanting-tumor of mouse colon cancer cell C26. Methods: The effects of the iridoid aglycones from Patrinia scabra(PS-I, BJ3401)on mouse colon cancer cell line C26 were studied by MTF experiment,the transplanting-tumor model of mouse colon cancer was established by hypodermic inoculating the mouse colon cancer cell lines C26 into the FI mice. Results: The iridoid aglycones PS -I and BJ3401 could significantly inhibit proliferation of C26 cell line in a doge-dependent manner,gross iridoid aglycones could sig- nificantly lessen the weight of the transplanting-tumor in mice.Conclusion :The iridoid aglycones from Patrinia scabra have anti-colon carcinoma activity.
Experimental study of Weichi liniment on treating acute soft tissue injury
DU Xing-dong, LIU Jun-quan, LI De-ben
2007, (1): 15-18.
Abstract(2183) PDF (439KB)(506)
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Objective:To study the therapeutic effect of Weichi liniment on acute soft-tissue injury. Methods: Animal models of acute soft-tissue injury were made in 30 healthy white rabbits,and the animals were randomly divided into three groups(n=10 rabbits each):Weichi liniment,honghuayou and control group.The therapeutic effects were observed by methods of gross and histology.Re- sults:Weichi liniment bears better dispelling action of edema,analgesic action and dispelling stasis.The inflammation response of Weichi group to trauma in histology was significantly lighter compared with other 2 groups. Conclusion: Weichi liniment could inhibit traumatic aseptic inflammation and exert an effect of relieving swelling and dispersing blood stasis and might be an ideal external used drug in treating acute soft tissue injury.
Studies of the pharmacokinetics of compound ampicillin sodium for injection
WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin
2007, (1): 18-20,30.
Abstract(2273) PDF (524KB)(120)
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Objective:To observe the characteristics of the pharmacokinetics of compound ampicillin sodium for injection.Meth- otis:The pharmacokinetics of ampieillin and probenecid in six rabbits after injection were measured by HPLC. Results: On calculation of quantity of ampieillin sodium,300 mg/kg compound ampicillin sodium increased the half life of ampicillin from(23±10)to(31±15)min and the value of A UC from(8.5±0.9 )to(6.2±0.8)mg/(h·mL),120 mg/kg compound ampicillin sodium increased the value of AUC from(2.8±0.9)to(5.7±1.0)mg/(h·mL),50 mg/kg compound ampicillin sodium increased the value of AUC from(0.7±0.2)to(1.5±0.3)mg/(h·mL). Conclusion: Compound ampicillin sodium for injection can increase the activity of ampicillin sodium.
Study on convolution transform and visualization of ultraviolet spectroscopic information of steroid hormones
YUAN Li-xia, ZHANG Zhong-hu, LU-feng
2007, (1): 21-22.
Abstract(2195) PDF (543KB)(392)
Abstract:
Objective:To establish a new analytical method for the identification of steroid hormones. Methods: Convolution trans- form combined with information visualization techniques were employed in the data mining of ultraviolet spectrum,resulting in the fin- gerprint spectrum of certain compounds.The similarity coefficient of fingerprint spectrum based on cosine algorithm was further used in the identification of 23 steroid hormones,ie.prednisolone,betamethasone,pregnendione,etc.,after the method was validated.Re- suits :The method showed acceptable precision and ruggedness.There were large differences between the similarity coefficients of differ- ent types of steroid hormones.The unsaturated bond contributed greatly to the differences between the similarity coefficients of same types of steroid hormones,while the side chain or its esterification had relatively small effect on the similarity coefficients. Conclusion: Convolution transform combined with information visualization techniques broadens the application of ultraviolet spectrum in the pharma- ceutical identification.
Study on the stability of compatibility of mezlocillin sodium in 5% xylitol injection
WANG Shu-jun, SHI Li, SHEN Xiao-fen
2007, (1): 22-24.
Abstract(2328) PDF (298KB)(155)
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Objective:To study the stability of compatibility of mezlocillin sodium in 5% xylitol injection at different temperature (25℃、37℃)winthin six hours.Methods :The content of mezlocillin was determined by UV-spectrophotometry,and the appearance of the solution was observed and its pH value was tested. Results: There were no significant changes in appearance,pH value and con- tent of the mixed solution winthin six hours. Conclusion: Mezlocillin sodium mixed with 5% xylitol injection can be used under above- mentioned conditions winthin six hours
Study on the stability of compatibility of mezlocillin sodium in 5 % xylitol injection
2007, (1): 24-26.
Abstract(1579) PDF (339KB)(165)
Abstract:
Study on stability of compatibility of fleroxacin and glucose injection with ribavirin injection
WU Xue, ZHANG Ying-hui, CHEN Jia, MO Xiao-jun
2007, (1): 26-30.
Abstract(1952) PDF (294KB)(172)
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Objective:To study the compatible stability of fleroxacin and glucose injection with ribavirin Injection. Methods: In the case of ambient temeratur(25℃),the changes in appearance and pH were observed,the content was determined by UV. Results: The average recoveries were 99.52% and 99.31%;RSD were 0.450% and 0.364%.The compatibility of fleroxaein and glucose injection with ribavirin injection had no significant changes in the aspect,pH,and content.Conclusin:The fleroxaein and glucose injection can be compatible with ribavirin injection,and be used within 6 h.
Improvement and stability of multi-effect gastroscope emulsion
YANG Zhen, YU Xi-quan, YAN Ming
2007, (1): 31-31.
Abstract(2126) PDF (586KB)(149)
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Objective:To enhance the stability and control quality of the multi-effect gastroscope emulsion by improving the pre- scription of emulsion. Methods: The different prescriptiones of the multi-effect gastroscope emulsion were tested and evaluated by mi- croscopy,centrifugal experiment,cold-resistant/heat-resistant experiment,room temperature storage test as well as the content-determi- nation. Results: The emulsion with 0.8% span-80,1.6% tragacantha or with 5% span-80,2% CMC-Na has a good stability.Conclu- sion:The prescriptions of the multi-effect gastroscope emulsion can be applied to preparation production.
Identification of pyridoxal phosphate by differential thermal analysis
LIN Jin-ming, BIAN Hong-ping, WAN Xiao-yan, HE Bang-ping, ZHOU Hou-yuan
2007, (1): 32-35.
Abstract(2228) PDF (197KB)(369)
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Objective:Comparison and identification of pyridoxal phosphate(including importation and own preparation).Meth- ods:TG/DTA scanning and analyse. Results: They were unanimous that characteristic thermal diagram of pyridoxal phosphate which importation and own reparation,this shows that own preparation was successful.At the same time difference that peaking temperature and the peaking area was due to their different purity. Conclusion: Differential thermal analysis method are simple and speedy for to i- dentification of materials.
Determination of the przewatanshinquinone in Tongmailing tabeles
XING Jun, LI Zheng-guo, ZHANG Zhong-hu
2007, (1): 35-37.
Abstract(2137) PDF (399KB)(204)
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Objective:To establish a HPLC method of the determination of the przewatanshinquinone in Tongmailing tabeles. Methods: The determination was performed by Re-HPLC on KromasilTM C18 column(200 mm×4.6 mm,5μm)using methanol-toni- trile-0.045 mol/L H3 PO4(10:4:86)as mobile phase,the detection wavelength was 281 nm. Results: The linear rang of przewatan- shinquinone was 0.194~2.129μg,r=0.999 8.The average recovery was 99.56%,RSD was 0.84%(n=5). Conclusion: The method is sensitive,simple,and good reproducibility,which can be applied to the quality control of the preparation.
Determination of icarrin in Yangjing capsule by HPLC
LU Xiao-he, JIN Bao-fang, WANG Xiu-lai
2007, (1): 37-38,53.
Abstract(2449) PDF (387KB)(254)
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Objective:To establish an HPLC method for determination of Icarrin in Yangjing Capsule. Methods: The determina- tion was performed on Phenomenex C18 column(250mm×4.6 mm,5μm).The mobile phase consisted of acetonitrile-water(30:70) with a flow rate of 0.8 mL/min.The detecting wavelength was at 270 nm. Results: The linear range of icarrin was 122.2~611.0 ng (r=0.9996).The average recovery was 98.2%(RSD:1.33% ). Conclusion: The established method is simple,convenient,accu- rate and reproducible,and suitable for the quality control of Icarrin content in Yangjing capsule.
Study of extraction technology of paeonol in Cortex Moutan
MENG Xi-cheng
2007, (1): 39-40.
Abstract(2520) PDF (323KB)(149)
Abstract:
Objective:To study the extraction technology of paeonol from Cortex Moutan,and improve the extraction method of steam distillation with ultrasonic assistance. Methods: The paeonol was determined by HPLC method in Chinese Pharmacopeia 2005. The distilled water amount,alcohol addition amount and uhransonic time,meanwhile were conpared,the extraction amounts of paeonol in distillate were calculated. Results: The final affirmed method of paeonol extraction was ten times distilled water and transonic twenty minutes,then distill until the distillate was not turbid. Conclusion: The final method was pretreated by ultrasonic which could increase the extraction efficiency greatly,and has the advantages of simple,economic and low toxicity,also can be used in the large-scale prep- aration of paeonol.
Study of extraction technology of paeonol in Cortex Moutan
2007, (1): 40-42.
Abstract(2231) PDF (335KB)(173)
Abstract:
Objective:To study the extraction technology of paeonol from Cortex Moutan,and improve the extraction method of steam distillation with ultrasonic assistance.Methods:The paeonol was determined by HPLC method in Chinese Pharmacopeia 2005. The distilled wat
2007, (1): 42-44.
Abstract(1840) PDF (610KB)(486)
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2007, (1): 44-45,49.
Abstract(1900) PDF (428KB)(214)
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2007, (1): 46-48.
Abstract(1877) PDF (348KB)(200)
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2007, (1): 50-50.
Abstract(1623) PDF (331KB)(231)
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2007, (1): 51-52.
Abstract(1784) PDF (241KB)(170)
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2007, (1): 52-53.
Abstract(1784) PDF (123KB)(134)
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2007, (1): 54-56.
Abstract(2086) PDF (232KB)(137)
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2007, (1): 57-60.
Abstract(1637) PDF (224KB)(184)
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2007, (1): 60-61.
Abstract(1432) PDF (324KB)(127)
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2007, (1): 62-64.
Abstract(2029) PDF (171KB)(125)
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2007, (1): 65-65.
Abstract(2142) PDF (577KB)(607)
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