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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (1): 18-20,30

WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
Citation: WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
shu

Studies of the pharmacokinetics of compound ampicillin sodium for injection

  • 1.

    Guangzhou Anjian Industrial Development Co.,Ltd.,Guangzhou 510420,China;Xi'an Jiaotong University,Xi'an 710061,China

  • 2.

    Xi'an Jiaotong University,Xi'an 710061,China

  • 3.

    Shenzhen Kangzhe Pharmaceutical Co.,Ltd.,Shenzhen 518029,China

  • 4.

    Guangzhou Institute for Drug Control,Guangzhou 510400,China

  • Received Date: 2005-01-11
  • Objective:To observe the characteristics of the pharmacokinetics of compound ampicillin sodium for injection.Meth- otis:The pharmacokinetics of ampieillin and probenecid in six rabbits after injection were measured by HPLC. Results: On calculation of quantity of ampieillin sodium,300 mg/kg compound ampicillin sodium increased the half life of ampicillin from(23±10)to(31±15)min and the value of A UC from(8.5±0.9 )to(6.2±0.8)mg/(h·mL),120 mg/kg compound ampicillin sodium increased the value of AUC from(2.8±0.9)to(5.7±1.0)mg/(h·mL),50 mg/kg compound ampicillin sodium increased the value of AUC from(0.7±0.2)to(1.5±0.3)mg/(h·mL). Conclusion: Compound ampicillin sodium for injection can increase the activity of ampicillin sodium.
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通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies of the pharmacokinetics of compound ampicillin sodium for injection

  • 1. Guangzhou Anjian Industrial Development Co.,Ltd.,Guangzhou 510420,China;Xi'an Jiaotong University,Xi'an 710061,China
  • 2. Xi'an Jiaotong University,Xi'an 710061,China
  • 3. Shenzhen Kangzhe Pharmaceutical Co.,Ltd.,Shenzhen 518029,China
  • 4. Guangzhou Institute for Drug Control,Guangzhou 510400,China
  • Received Date: 2005-01-11

Abstract: Objective:To observe the characteristics of the pharmacokinetics of compound ampicillin sodium for injection.Meth- otis:The pharmacokinetics of ampieillin and probenecid in six rabbits after injection were measured by HPLC. Results: On calculation of quantity of ampieillin sodium,300 mg/kg compound ampicillin sodium increased the half life of ampicillin from(23±10)to(31±15)min and the value of A UC from(8.5±0.9 )to(6.2±0.8)mg/(h·mL),120 mg/kg compound ampicillin sodium increased the value of AUC from(2.8±0.9)to(5.7±1.0)mg/(h·mL),50 mg/kg compound ampicillin sodium increased the value of AUC from(0.7±0.2)to(1.5±0.3)mg/(h·mL). Conclusion: Compound ampicillin sodium for injection can increase the activity of ampicillin sodium.

WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
Citation: WANG Pei-xian, CAO Yong-xiao, YANG Xiao-jiang, YAO Hong-ping, WANG Xiu-qin. Studies of the pharmacokinetics of compound ampicillin sodium for injection[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 18-20,30.
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