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HU Chaoqi. Study on the correlation between the quality parameters of silicone rubber and the releasing of fluorouracil implants[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 65-68. doi: 10.3969/j.issn.1006-0111.2019.01.015
Citation: YUAN Li-xia, ZHANG Zhong-hu, LU-feng. Study on convolution transform and visualization of ultraviolet spectroscopic information of steroid hormones[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 21-22.

Study on convolution transform and visualization of ultraviolet spectroscopic information of steroid hormones

  • Received Date: 2006-08-27
  • Objective:To establish a new analytical method for the identification of steroid hormones. Methods: Convolution trans- form combined with information visualization techniques were employed in the data mining of ultraviolet spectrum,resulting in the fin- gerprint spectrum of certain compounds.The similarity coefficient of fingerprint spectrum based on cosine algorithm was further used in the identification of 23 steroid hormones,ie.prednisolone,betamethasone,pregnendione,etc.,after the method was validated.Re- suits :The method showed acceptable precision and ruggedness.There were large differences between the similarity coefficients of differ- ent types of steroid hormones.The unsaturated bond contributed greatly to the differences between the similarity coefficients of same types of steroid hormones,while the side chain or its esterification had relatively small effect on the similarity coefficients. Conclusion: Convolution transform combined with information visualization techniques broadens the application of ultraviolet spectrum in the pharma- ceutical identification.
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    1. 胡娟, 张爱霞, 陈莉, 李文强, 曾向宏. 2019年国内有机硅进展. 有机硅材料. 2020(03): 68-94 .

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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on convolution transform and visualization of ultraviolet spectroscopic information of steroid hormones

Abstract: Objective:To establish a new analytical method for the identification of steroid hormones. Methods: Convolution trans- form combined with information visualization techniques were employed in the data mining of ultraviolet spectrum,resulting in the fin- gerprint spectrum of certain compounds.The similarity coefficient of fingerprint spectrum based on cosine algorithm was further used in the identification of 23 steroid hormones,ie.prednisolone,betamethasone,pregnendione,etc.,after the method was validated.Re- suits :The method showed acceptable precision and ruggedness.There were large differences between the similarity coefficients of differ- ent types of steroid hormones.The unsaturated bond contributed greatly to the differences between the similarity coefficients of same types of steroid hormones,while the side chain or its esterification had relatively small effect on the similarity coefficients. Conclusion: Convolution transform combined with information visualization techniques broadens the application of ultraviolet spectrum in the pharma- ceutical identification.

HU Chaoqi. Study on the correlation between the quality parameters of silicone rubber and the releasing of fluorouracil implants[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 65-68. doi: 10.3969/j.issn.1006-0111.2019.01.015
Citation: YUAN Li-xia, ZHANG Zhong-hu, LU-feng. Study on convolution transform and visualization of ultraviolet spectroscopic information of steroid hormones[J]. Journal of Pharmaceutical Practice and Service, 2007, (1): 21-22.

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