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Volume 25 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (2): 102-103

SHAO LV-cheng, CHEN Hong, WANG Xiao-yan, HE Bang-ping, LV Jia-guo, SHENG Chun-quan. Optimization of the synthesis of econazole nitrate by orthogonal experimental design[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 102-103.
Citation: SHAO LV-cheng, CHEN Hong, WANG Xiao-yan, HE Bang-ping, LV Jia-guo, SHENG Chun-quan. Optimization of the synthesis of econazole nitrate by orthogonal experimental design[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 102-103.
shu

Optimization of the synthesis of econazole nitrate by orthogonal experimental design

  • 1.

    Graduate Administration Division,Second Military Medical University,Shanghai,200433,China

  • 2.

    School of Pharmacy,Second Military Medical University,Shanghai,200433,China

  • Received Date: 2006-08-30
  • Objective: To optimize the synthesis of econazole nitrate,a useful antifungal agent. Methods: Orthogonal experimen-tal design is used and the influence of temperature,catalyst,reaction time and solvent on the yield is investigated. Results: Solvent is more important than reaction time and catalyst. Conclusion: The new method has several advantages such as cheap reactants,facile reaction condition,convenient operation and high yield.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Optimization of the synthesis of econazole nitrate by orthogonal experimental design

  • 1. Graduate Administration Division,Second Military Medical University,Shanghai,200433,China
  • 2. School of Pharmacy,Second Military Medical University,Shanghai,200433,China
  • Received Date: 2006-08-30

Abstract: Objective: To optimize the synthesis of econazole nitrate,a useful antifungal agent. Methods: Orthogonal experimen-tal design is used and the influence of temperature,catalyst,reaction time and solvent on the yield is investigated. Results: Solvent is more important than reaction time and catalyst. Conclusion: The new method has several advantages such as cheap reactants,facile reaction condition,convenient operation and high yield.

SHAO LV-cheng, CHEN Hong, WANG Xiao-yan, HE Bang-ping, LV Jia-guo, SHENG Chun-quan. Optimization of the synthesis of econazole nitrate by orthogonal experimental design[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 102-103.
Citation: SHAO LV-cheng, CHEN Hong, WANG Xiao-yan, HE Bang-ping, LV Jia-guo, SHENG Chun-quan. Optimization of the synthesis of econazole nitrate by orthogonal experimental design[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 102-103.
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