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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (2): 85-87

LIN Huan-bing, ZHONG Wen, LI Tie-jun, RUI Yao-cheng, XU Jiang-Ping, ZHANG Wei-Dong. Influence of Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobarbital sodium in mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 85-87.
Citation: LIN Huan-bing, ZHONG Wen, LI Tie-jun, RUI Yao-cheng, XU Jiang-Ping, ZHANG Wei-Dong. Influence of Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobarbital sodium in mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 85-87.
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Influence of Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobarbital sodium in mice

  • 1.

    Department of Pharmacology,Southern Medical University,Guangzhou 510515,China

  • 2.

    Department of HBO,No.422 Hospital of PLA,Zhanjiang 534005,China

  • 3.

    School of Pharmacy,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2006-12-25
  • Objective: To survey the influence of the Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobar-bital sodium in mice. Methods: ICR mice were randomly divided into 4 equal groups(Dengzhanxixin injection group,breviscapine group,naloxone hydrochloride group and sodium chloride group),effects of drug on mice hypnosis induced by pentoharbital sodium in suprathreshold dose or hypnotic dose was observed.Effects of drugs on mice spontaneous movement and equilibrium function was also observed. Results: Comparing with the group of sodium chloride,the group of Dengzhanxixin injection,breviscapine and naloxone hydrochloride significantly prolonged the time of falling asleep,shorted the duration of hypnosis induced by pentobarbital sodium in su-prathreshold dose in mice respectively(P＜0.05),shorted vanishing period of righting reflex in the mice induced by pentobarbital sodi-um in hypnotic dose(P＜0.05 ). Conclusion: Dengzhanxixin injection and breviscapine had arousal effects on pentobarbital sodium treated mice.
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Influence of Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobarbital sodium in mice

  • 1. Department of Pharmacology,Southern Medical University,Guangzhou 510515,China
  • 2. Department of HBO,No.422 Hospital of PLA,Zhanjiang 534005,China
  • 3. School of Pharmacy,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2006-12-25

Abstract: Objective: To survey the influence of the Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobar-bital sodium in mice. Methods: ICR mice were randomly divided into 4 equal groups(Dengzhanxixin injection group,breviscapine group,naloxone hydrochloride group and sodium chloride group),effects of drug on mice hypnosis induced by pentoharbital sodium in suprathreshold dose or hypnotic dose was observed.Effects of drugs on mice spontaneous movement and equilibrium function was also observed. Results: Comparing with the group of sodium chloride,the group of Dengzhanxixin injection,breviscapine and naloxone hydrochloride significantly prolonged the time of falling asleep,shorted the duration of hypnosis induced by pentobarbital sodium in su-prathreshold dose in mice respectively(P＜0.05),shorted vanishing period of righting reflex in the mice induced by pentobarbital sodi-um in hypnotic dose(P＜0.05 ). Conclusion: Dengzhanxixin injection and breviscapine had arousal effects on pentobarbital sodium treated mice.

LIN Huan-bing, ZHONG Wen, LI Tie-jun, RUI Yao-cheng, XU Jiang-Ping, ZHANG Wei-Dong. Influence of Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobarbital sodium in mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 85-87.
Citation: LIN Huan-bing, ZHONG Wen, LI Tie-jun, RUI Yao-cheng, XU Jiang-Ping, ZHANG Wei-Dong. Influence of Dengzhanxixin injection and breviscapine on the hypnotic effects of pentobarbital sodium in mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 85-87.
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