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Volume 25 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (2): 100-101

LI Qi, WANG Feng-shan, LING Pei-xue, ZHANG Tian-min. Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 100-101.
Citation: LI Qi, WANG Feng-shan, LING Pei-xue, ZHANG Tian-min. Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 100-101.
shu

Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops

  • 1.

    Pharmacy School of Shandong University,Jinan 250012,China;Department of Pharmacy,The Chest Hospital of Shandong Province,Jinan 250013,China

  • 2.

    Pharmacy School of Shandong University,Jinan 250012,China

  • Received Date: 2006-04-14
  • Objective: To study the influence factores of chloramphenicol release with sodium hyaluronate as vehicle in eye drops. Methods: The penetration rates of chloramphenicol were determined with modified Franz diffusion cell in solutions with different influ-ence factores. Results: The increase of solution viscosity could decrease the release rate of chloramphenicol.The release rates of chlor-amphenicol decreased with the concentrations of sodium hyaluronate increased and increased with the concentrations of chloramphenicol increased. Conclusion: The release rate of chloramphenicol in eye drops is concerned with viscosity of solution and drug concentration, but there is a limite to the drug sustained release by increasing viscosity of solution.
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Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops

  • 1. Pharmacy School of Shandong University,Jinan 250012,China;Department of Pharmacy,The Chest Hospital of Shandong Province,Jinan 250013,China
  • 2. Pharmacy School of Shandong University,Jinan 250012,China
  • Received Date: 2006-04-14

Abstract: Objective: To study the influence factores of chloramphenicol release with sodium hyaluronate as vehicle in eye drops. Methods: The penetration rates of chloramphenicol were determined with modified Franz diffusion cell in solutions with different influ-ence factores. Results: The increase of solution viscosity could decrease the release rate of chloramphenicol.The release rates of chlor-amphenicol decreased with the concentrations of sodium hyaluronate increased and increased with the concentrations of chloramphenicol increased. Conclusion: The release rate of chloramphenicol in eye drops is concerned with viscosity of solution and drug concentration, but there is a limite to the drug sustained release by increasing viscosity of solution.

LI Qi, WANG Feng-shan, LING Pei-xue, ZHANG Tian-min. Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 100-101.
Citation: LI Qi, WANG Feng-shan, LING Pei-xue, ZHANG Tian-min. Influence of sodium hyaluronate as vehicle on chloramphenicol release in eye drops[J]. Journal of Pharmaceutical Practice and Service, 2007, (2): 100-101.
shu

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