Determination of the dissociation constant and partition coefficient of mesylate delavirdine
- Received Date: 2007-04-09
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Key words:
- mesylate delavirdine /
- ionization constant /
- partition coefficient /
- acid-base titration.
Abstract: Objective : To determine the dissociation constant and partition coefficient of mesylate delavirdine. Methods :The dissociation constant was determined with acid-base titration method in methanol /water solutions with different ratios,the value to infinite diluted in pure water was extrapolated and the partition coefficient was determined with bottle-shaking method by HPLC. Results : The pKa and 1gP of mesylate delavirdine in n-octyl alcohol were 4.635 and 2.907 respectively. Conclusions : mesylate delavirdine is a weak acid with lipophilic property.
Citation: | GUAN Qing-xiang, LIN Tian-mu, WANG En-si. Determination of the dissociation constant and partition coefficient of mesylate delavirdine[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 290-291. |