Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 25 Issue 5
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (5): 295-296,302

ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
Citation: ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
shu

Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice

  • Shanghai University of Traditional Chinese Medecine, Shanghai 201203, China

  • Received Date: 2007-05-14
  • Objective :To study the angiogenesis effects of Shexiang Baoxin pill on cancer. Methods :The model of liver metastasis of colorectal cancer was established on 40 BALB/C nude mice which were xenotransplanted through intraspleen injection of LoVo cells,a human colon cancer cell line.These mice were divided into four groups randomly as following: the high-dose-group with Shexiang Baoxin Pill,the medium-dose-group with Shexiang Baoxin Pill,the low-dose-group with Shexiang Baoxin Pill and the model group.The rats of each group were given intragastric administration every day.After 35 days of treatment,vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and Ⅷ-R Ag were messured by immunohistochemical staining. Results :The contents of VEGF,bFGF and Ⅷ-R Ag in herb groups were significantly lower than that of the model group(P<0.05). Conclusion : Shexiang Baoxin Pill can obviously inhibit the angiogeneses in cancer tissues.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2568) PDF downloads(34) Cited by()

Related
Proportional views

Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice

  • Shanghai University of Traditional Chinese Medecine, Shanghai 201203, China
  • Received Date: 2007-05-14

Abstract: Objective :To study the angiogenesis effects of Shexiang Baoxin pill on cancer. Methods :The model of liver metastasis of colorectal cancer was established on 40 BALB/C nude mice which were xenotransplanted through intraspleen injection of LoVo cells,a human colon cancer cell line.These mice were divided into four groups randomly as following: the high-dose-group with Shexiang Baoxin Pill,the medium-dose-group with Shexiang Baoxin Pill,the low-dose-group with Shexiang Baoxin Pill and the model group.The rats of each group were given intragastric administration every day.After 35 days of treatment,vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and Ⅷ-R Ag were messured by immunohistochemical staining. Results :The contents of VEGF,bFGF and Ⅷ-R Ag in herb groups were significantly lower than that of the model group(P<0.05). Conclusion : Shexiang Baoxin Pill can obviously inhibit the angiogeneses in cancer tissues.

ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
Citation: ZHANG Chen, CHENG Kang, GUO Wei, WEI Hong-chang. Effects of Shexiang Baoxin pill on Preangiogenesis factors and tumor growth of human colon cancer liver metastasis in nude mice[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 295-296,302.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return