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HU Jian-guo, LIU Chang-hai. Determination of fourteen kinds of organic residual in olmesartan medoxomil by capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 300-302.
Citation: HU Jian-guo, LIU Chang-hai. Determination of fourteen kinds of organic residual in olmesartan medoxomil by capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 300-302.

Determination of fourteen kinds of organic residual in olmesartan medoxomil by capillary gas chromatography

  • Received Date: 2007-05-14
  • Objective :To establish by capillary gas chromatography for the analysis of organic residual in olmesartan medoxomil by direct injection of solution,and compare with the results. Methods :Wide-bore capillary column(30m ×0.53mm) packed with 6% cyanopropylphenyl-94% dimethylpoly-siloxane(deep film 3μm)was used on a programmed column temperature.DMSO was used as solvent,and samples were injected for the analysis. Results :The calibration curves of methanol,ethanol,ether,acetone,acetonitrile,dichloromethane,n-hexane,isopropylether,ethyl acetate,chloroform,dioxane,toluene,dimethylformam-ide and xylene showed good linearity.The average recoveries were good.The detection limits were 0.4 ng,0.4 ng,1.6 ng,1.2 ng,0.7 ng,2.0 ng,0.5 ng,1.5 ng,0.8 ng,3.3 ng,0.6 ng,0.3 ng,2.8 ng和0.8 ng,respectively. Conclusion :The results showed that the method can be used to detect the organic residual in olmesartan medoxomil,the method have high sensitivity and good repetition.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Determination of fourteen kinds of organic residual in olmesartan medoxomil by capillary gas chromatography

Abstract: Objective :To establish by capillary gas chromatography for the analysis of organic residual in olmesartan medoxomil by direct injection of solution,and compare with the results. Methods :Wide-bore capillary column(30m ×0.53mm) packed with 6% cyanopropylphenyl-94% dimethylpoly-siloxane(deep film 3μm)was used on a programmed column temperature.DMSO was used as solvent,and samples were injected for the analysis. Results :The calibration curves of methanol,ethanol,ether,acetone,acetonitrile,dichloromethane,n-hexane,isopropylether,ethyl acetate,chloroform,dioxane,toluene,dimethylformam-ide and xylene showed good linearity.The average recoveries were good.The detection limits were 0.4 ng,0.4 ng,1.6 ng,1.2 ng,0.7 ng,2.0 ng,0.5 ng,1.5 ng,0.8 ng,3.3 ng,0.6 ng,0.3 ng,2.8 ng和0.8 ng,respectively. Conclusion :The results showed that the method can be used to detect the organic residual in olmesartan medoxomil,the method have high sensitivity and good repetition.

HU Jian-guo, LIU Chang-hai. Determination of fourteen kinds of organic residual in olmesartan medoxomil by capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 300-302.
Citation: HU Jian-guo, LIU Chang-hai. Determination of fourteen kinds of organic residual in olmesartan medoxomil by capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 300-302.

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