Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro
- Received Date: 2007-07-24
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Key words:
- Silver Norfloxacin /
- Zinc Norfloxacin /
- Cerous Norfloxacin /
- Chloriole Norfloxacin /
- Bismuth Norfloxacin /
- preparation /
- synthesis bacteriostatic activity.
Abstract: Objective :To synthesize metallic salts of norfloxacin(NFLO) and evaluate their bacteriaostatic activities in vitro. Methods : The compounds were syntherized from the starting material norfloxacin and metallic salts.The bateriostatic activities of these new compounds were tested. Results : Five new compounds(NFLO-Ag,,NFLO-Zn,NFLO-Ce,NFLO-Co,NFLO-Bi) were produced and their primary quality criteria were established. Conclusions : The bateriostatic tests showed that these new compounds exhibit more potent antimicrobial activities than sliver sulfadiazine against Escherichia coli,Staphylococcus aureus and Pseudomonas aeruginosa.
Citation: | HE Quan-shan, YANG Chang-yun, CHEN Wei-zhong, YANG Xiang-yue, RONG Jiang-kai. Synthesis and bacteriostatic activity of the metallic salts of norfloxacin in vitro[J]. Journal of Pharmaceutical Practice and Service, 2007, (5): 303-306. |