Improvement of the synthetic process of 7-azaindol-3-carboxylic acid

Key words: 
• 7-Azaindol-3-carboxylic acid /
• synthesis /
• technical improvement

Abstract: Objective : To improve the synthetic process of 7-azaindol-3-carboxylic acid. Methods : The succinonitrile was taken as the original raw material.The isopropyl ether,n-heptane,and chlorobenzene, which were used in original technics,were subsituted by ethyl acetate,petroleun ether,and xylene respectively.The disposition technics was optimized. Results : The technics was successfully improved due to its low cost,small toxicity,convenient disposition and high yield. Conclusions : The higher overall yields was 43.4%.This improved method is more suitable for industrial production for its low cost.