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Volume 25 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (6): 403-404

DONG Ling-ling, CAO Ying-ying, CHAI Yi-feng. Determination of trehalose in Candida albicans by HPLC-MS[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 186-188.
Citation: LI Qun-an. Study on the pharmacokinetics of caffeine in male at different ages[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 403-404.
shu

Study on the pharmacokinetics of caffeine in male at different ages

  • No.303 Hospital of PLA,Nanning 530021,China

  • Received Date: 2007-07-02
  • Objective :To obtain the pharmacokinetics parameters of caffeine in the elderly,presenile,pastadolescenal and young male. Methods :Saliva caffeine(CAF) concentration in 16 old male(aged 67～81 years),20 presenile male(aged 51～60 years),46 pastadolescenal male(aged 35～50 years) and 95 young male(aged 18～34 years) was determined by RP-HPLC method,and according to the saliva concentration time curves,the pharmacokinetic parameters were calculated. Results : The saliva CAF1/2 in the elderly group was significantly increased to those in the other group(P<0.000 5,P<0.000 1,P<0.01),the saliva CAF clearanc was significantly decreased(P<0.000 2,P<0.002,P<0.01) and apparent volume of distribution(Vd) was not different significantly(P>0.05). Conclusion : The saliva CAF1/2 and clearanc in the elderly male were significantly increased and decreased respectively,Vd was not different significantly.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 25.3 %其他: 25.3 %China: 0.3 %China: 0.3 %United States: 0.3 %United States: 0.3 %上海: 0.9 %上海: 0.9 %北京: 14.6 %北京: 14.6 %台州: 2.1 %台州: 2.1 %呼和浩特: 0.3 %呼和浩特: 0.3 %张家口: 0.3 %张家口: 0.3 %新竹: 0.3 %新竹: 0.3 %杭州: 1.8 %杭州: 1.8 %梧州: 0.3 %梧州: 0.3 %湖州: 0.3 %湖州: 0.3 %芒廷维尤: 29.0 %芒廷维尤: 29.0 %衢州: 2.4 %衢州: 2.4 %西宁: 20.7 %西宁: 20.7 %郑州: 0.3 %郑州: 0.3 %金华: 0.6 %金华: 0.6 %其他ChinaUnited States上海北京台州呼和浩特张家口新竹杭州梧州湖州芒廷维尤衢州西宁郑州金华Highcharts.com
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Study on the pharmacokinetics of caffeine in male at different ages

  • No.303 Hospital of PLA,Nanning 530021,China
  • Received Date: 2007-07-02

Abstract: Objective :To obtain the pharmacokinetics parameters of caffeine in the elderly,presenile,pastadolescenal and young male. Methods :Saliva caffeine(CAF) concentration in 16 old male(aged 67～81 years),20 presenile male(aged 51～60 years),46 pastadolescenal male(aged 35～50 years) and 95 young male(aged 18～34 years) was determined by RP-HPLC method,and according to the saliva concentration time curves,the pharmacokinetic parameters were calculated. Results : The saliva CAF1/2 in the elderly group was significantly increased to those in the other group(P<0.000 5,P<0.000 1,P<0.01),the saliva CAF clearanc was significantly decreased(P<0.000 2,P<0.002,P<0.01) and apparent volume of distribution(Vd) was not different significantly(P>0.05). Conclusion : The saliva CAF1/2 and clearanc in the elderly male were significantly increased and decreased respectively,Vd was not different significantly.

DONG Ling-ling, CAO Ying-ying, CHAI Yi-feng. Determination of trehalose in Candida albicans by HPLC-MS[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 186-188.
Citation: LI Qun-an. Study on the pharmacokinetics of caffeine in male at different ages[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 403-404.
shu

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