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Volume 25 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2007  >  (6): 403-404

LI Qun-an. Study on the pharmacokinetics of caffeine in male at different ages[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 403-404.
Citation: LI Qun-an. Study on the pharmacokinetics of caffeine in male at different ages[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 403-404.
shu

Study on the pharmacokinetics of caffeine in male at different ages

  • No.303 Hospital of PLA,Nanning 530021,China

  • Received Date: 2007-07-02
  • Objective :To obtain the pharmacokinetics parameters of caffeine in the elderly,presenile,pastadolescenal and young male. Methods :Saliva caffeine(CAF) concentration in 16 old male(aged 67～81 years),20 presenile male(aged 51～60 years),46 pastadolescenal male(aged 35～50 years) and 95 young male(aged 18～34 years) was determined by RP-HPLC method,and according to the saliva concentration time curves,the pharmacokinetic parameters were calculated. Results : The saliva CAF1/2 in the elderly group was significantly increased to those in the other group(P<0.000 5,P<0.000 1,P<0.01),the saliva CAF clearanc was significantly decreased(P<0.000 2,P<0.002,P<0.01) and apparent volume of distribution(Vd) was not different significantly(P>0.05). Conclusion : The saliva CAF1/2 and clearanc in the elderly male were significantly increased and decreased respectively,Vd was not different significantly.
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Study on the pharmacokinetics of caffeine in male at different ages

  • No.303 Hospital of PLA,Nanning 530021,China
  • Received Date: 2007-07-02

Abstract: Objective :To obtain the pharmacokinetics parameters of caffeine in the elderly,presenile,pastadolescenal and young male. Methods :Saliva caffeine(CAF) concentration in 16 old male(aged 67～81 years),20 presenile male(aged 51～60 years),46 pastadolescenal male(aged 35～50 years) and 95 young male(aged 18～34 years) was determined by RP-HPLC method,and according to the saliva concentration time curves,the pharmacokinetic parameters were calculated. Results : The saliva CAF1/2 in the elderly group was significantly increased to those in the other group(P<0.000 5,P<0.000 1,P<0.01),the saliva CAF clearanc was significantly decreased(P<0.000 2,P<0.002,P<0.01) and apparent volume of distribution(Vd) was not different significantly(P>0.05). Conclusion : The saliva CAF1/2 and clearanc in the elderly male were significantly increased and decreased respectively,Vd was not different significantly.

LI Qun-an. Study on the pharmacokinetics of caffeine in male at different ages[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 403-404.
Citation: LI Qun-an. Study on the pharmacokinetics of caffeine in male at different ages[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 403-404.
shu

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