Dissolution of naproxen sodium tablets and evaluation of in vitro-in vivo correlation about this drug
- Received Date: 2007-07-24
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Key words:
- naproxen sodium tablets /
- dissolution /
- in vitro and in vivo correlation
Abstract: Objective: To study the dissolution of naproxen sodium tablets and evaluate in vitro / in vivo correlation. Methods: Dissolution test method in naproxen sodium tablets adopted by USP was used for determination of dissolution in vitro.The concentrations of naproxen sodium tablets in human plasma were determined by HPLC. Results: The linear equation based on the dissolution rate(X) and absorption percentage(F) was F=0.330 3X+0.699 8 and the correlation coefficient was 0.991 5. Conclusion: To a certain extent,the in vitro dissolution test in USP could reflect the in vivo absorption.
Citation: | LE Jian, LIU Qian, SHI Jin-min, CHEN Gui-liang. Dissolution of naproxen sodium tablets and evaluation of in vitro-in vivo correlation about this drug[J]. Journal of Pharmaceutical Practice and Service, 2008, (3): 211-213. |