Studies on safety and effecting factors of floating tablets in stomach with 99mTc
- Received Date: 2008-12-01
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Key words:
- floating tablet /
- isotop tracing /
- sefety
Abstract: Objective : To study the method of tracing the floating tablet with isotope in the stomach and discuss the security and the influence factors to the floating tablet detained in the stomach. Methods :The 99mTc as the sign was added to the raw material of tablet by ECT.The images in the stomach were checked and the residual quantity of isotope in intestine,urine and excrement was traced. Results :The image of tablet in the stomach was clear.The radioactivity can not traced in excreta of volunteer 48 h later.After meal,the detained time of floating in stomach can be prolonged. Conclusion :The floating tablets could be traced with 99mTc and collected the images with ECT.It is safe if only control the total of isotope.The major factor of affecting the detained time of the floating tablets is the food in the stomach.
Citation: | LIU Fu-qiang, CHE Yan-zhi, SUN Dan, ZHAO Hui-ying. Studies on safety and effecting factors of floating tablets in stomach with 99mTc[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 104-106,110. |