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Volume 27 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(2): 123-125

GONG Yan-ling, WANG Hong-bo. Protective effect of compound Yinhu decoction on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 123-125.
Citation: GONG Yan-ling, WANG Hong-bo. Protective effect of compound Yinhu decoction on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 123-125.
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Protective effect of compound Yinhu decoction on experimental liver injury

  • 1.

    Pharmaceutical department, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

  • 2.

    Jimo of People's hospital, Jimo 266200, China

  • Received Date: 2008-09-25
  • Objective : To observe the protective effect of Compound Yinhu decoction on acute liver injury induced by carbon tetrachloride(CCl4) in mice. Methods : Acute liver injury was established by intraperitoneal injection of CCl4.Compound Yinhu decotion was tested as subjects drug and bifendate as a positive control drug.The liver index(LI),the levels of serum alanine amino-transferase(ALT) and aspartate amino-transferase(AST),the superoxide dismutase(SOD) and molondialdehyde(MDA) levels in the liver tissue were measured and the protective effect of Compound Yinhu decotion on liver injury was observed. Results :Compound Yinhu decotion could significantly reduce serum ALT and AST levels,increase liver SOD level and decrease liver MDA level.It could also reduce the liver cell morphological injury. Conclusions :Compound Yinhu decotion has some protective effect on acute liver injury induced by CCl4 in mice.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Protective effect of compound Yinhu decoction on experimental liver injury

  • 1. Pharmaceutical department, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
  • 2. Jimo of People's hospital, Jimo 266200, China
  • Received Date: 2008-09-25

Abstract: Objective : To observe the protective effect of Compound Yinhu decoction on acute liver injury induced by carbon tetrachloride(CCl4) in mice. Methods : Acute liver injury was established by intraperitoneal injection of CCl4.Compound Yinhu decotion was tested as subjects drug and bifendate as a positive control drug.The liver index(LI),the levels of serum alanine amino-transferase(ALT) and aspartate amino-transferase(AST),the superoxide dismutase(SOD) and molondialdehyde(MDA) levels in the liver tissue were measured and the protective effect of Compound Yinhu decotion on liver injury was observed. Results :Compound Yinhu decotion could significantly reduce serum ALT and AST levels,increase liver SOD level and decrease liver MDA level.It could also reduce the liver cell morphological injury. Conclusions :Compound Yinhu decotion has some protective effect on acute liver injury induced by CCl4 in mice.

GONG Yan-ling, WANG Hong-bo. Protective effect of compound Yinhu decoction on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 123-125.
Citation: GONG Yan-ling, WANG Hong-bo. Protective effect of compound Yinhu decoction on experimental liver injury[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 123-125.
shu

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