Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 2
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(2): 126-128

MAO Jun-Qin, YI Jia, LI Tie-Jun. Studies on the anti-depressant effects of Akebia fruit alcohol extract[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 126-128.
Citation: MAO Jun-Qin, YI Jia, LI Tie-Jun. Studies on the anti-depressant effects of Akebia fruit alcohol extract[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 126-128.
shu

Studies on the anti-depressant effects of Akebia fruit alcohol extract

  • 1.

    Department of Pharmacy, the 85th Hospital of PLA, Shanghai 200053, China

  • 2.

    Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-12-08
  • Objective : To investigate the anti-depressant effects of Akebia fruit alcohol extract and to explore its mechanism. Methods :Tail suspension model and force-swim model of mice were used to observe the effect of Akebia fruit alcohol extract on relieving depression.The mechanism was examined by inhibiting reuptake of monoamine neurotransmitters. Results :Akebia fruit alcohol extract can reduced the immobility time in both of the tail suspension test and the forced swim test of mice.Akebia fruit alcohol extract significantly increased the rate of death of injecting dopamine and enhanced the apomorphine-induced stereotypy,could increase the head-twitch response evoked by 5-HTP,but it had no direct activation on reuptake of noradrenalin. Conclusion :Akebia fruit alcohol extract has antidepressant effects,and its mechanism may be related to the reinforcement of 5-HT nerves system and DA nerves system.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2432) PDF downloads(1004) Cited by()

Related
Proportional views

Studies on the anti-depressant effects of Akebia fruit alcohol extract

  • 1. Department of Pharmacy, the 85th Hospital of PLA, Shanghai 200053, China
  • 2. Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-12-08

Abstract: Objective : To investigate the anti-depressant effects of Akebia fruit alcohol extract and to explore its mechanism. Methods :Tail suspension model and force-swim model of mice were used to observe the effect of Akebia fruit alcohol extract on relieving depression.The mechanism was examined by inhibiting reuptake of monoamine neurotransmitters. Results :Akebia fruit alcohol extract can reduced the immobility time in both of the tail suspension test and the forced swim test of mice.Akebia fruit alcohol extract significantly increased the rate of death of injecting dopamine and enhanced the apomorphine-induced stereotypy,could increase the head-twitch response evoked by 5-HTP,but it had no direct activation on reuptake of noradrenalin. Conclusion :Akebia fruit alcohol extract has antidepressant effects,and its mechanism may be related to the reinforcement of 5-HT nerves system and DA nerves system.

MAO Jun-Qin, YI Jia, LI Tie-Jun. Studies on the anti-depressant effects of Akebia fruit alcohol extract[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 126-128.
Citation: MAO Jun-Qin, YI Jia, LI Tie-Jun. Studies on the anti-depressant effects of Akebia fruit alcohol extract[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 126-128.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return