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CHEN Fu-chao, LI Qin, LI Peng, FANG Bao-xia, CHEN Qin-hua, ZHU Jun. Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 132-133,145.
Citation: CHEN Fu-chao, LI Qin, LI Peng, FANG Bao-xia, CHEN Qin-hua, ZHU Jun. Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 132-133,145.

Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection

  • Received Date: 2008-08-28
  • Objective : To study the stability of the mixture of potassium sodium dehydroandrographolide succinate for injection with cefuroxime sodium injection in 0.9% sodium chloride injection. Methods : HPLC method was adopted.The contents were determined after mixing of potassium sodium dehydroandrographolide succinate with Cefuroxime injection in 0.9% sodium chloride injection under the room temperature within 8 hours,and the appearance of the solution was observed and its pH value was determined. Results :No significant differences were found in terms of pH value,but the colour gradually deepens as time goes on.The relative percentage of cefuroxime sodium drops to below 95% after 5 h,and the degradation product peak area accounts for the total peak area percentage to surpass 1% after 4 h. Conclusions :The mixture of potassium sodium dehydroandrographolide succinate with cefuroxime sodium injection in 0.9% sodium chloride injection can be used in NS under room temperature,but must be injected during 4 hours.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection

Abstract: Objective : To study the stability of the mixture of potassium sodium dehydroandrographolide succinate for injection with cefuroxime sodium injection in 0.9% sodium chloride injection. Methods : HPLC method was adopted.The contents were determined after mixing of potassium sodium dehydroandrographolide succinate with Cefuroxime injection in 0.9% sodium chloride injection under the room temperature within 8 hours,and the appearance of the solution was observed and its pH value was determined. Results :No significant differences were found in terms of pH value,but the colour gradually deepens as time goes on.The relative percentage of cefuroxime sodium drops to below 95% after 5 h,and the degradation product peak area accounts for the total peak area percentage to surpass 1% after 4 h. Conclusions :The mixture of potassium sodium dehydroandrographolide succinate with cefuroxime sodium injection in 0.9% sodium chloride injection can be used in NS under room temperature,but must be injected during 4 hours.

CHEN Fu-chao, LI Qin, LI Peng, FANG Bao-xia, CHEN Qin-hua, ZHU Jun. Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 132-133,145.
Citation: CHEN Fu-chao, LI Qin, LI Peng, FANG Bao-xia, CHEN Qin-hua, ZHU Jun. Compatible stability of potassium sodium dehydroandrographolide succinate for injection and cefuroxime sodium injection[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(2): 132-133,145.

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