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Volume 27 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(6): 414-416,420

JIANG Guo-jun, LU Ming-Zhu, YI Jia. Protective effect of procyanidine on PC12 cells injury induced by H2O2[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 414-416,420.
Citation: JIANG Guo-jun, LU Ming-Zhu, YI Jia. Protective effect of procyanidine on PC12 cells injury induced by H2O2[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 414-416,420.
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Protective effect of procyanidine on PC12 cells injury induced by H2O2

  • 1.

    Department of Pharmacy, Zhejiang Xiaoshan Hospital;Hangzhou 311201, China

  • 2.

    Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

  • Received Date: 2009-07-08
  • Objective :To investigate the protective effect of procyanidine on the injury of PC12 cells induced by H2O2. Methods :The PC12 cells were injuried induced by H2O2.The cel1 activity was determined by MTT.The cell apoptosis rate were detected by flow cytometry.Proteins of Bcl-2 and Bax were detected by immunohistochemistry. Results :Procyanidine increased the survival rate and decreased the apoptotic rate of PC12 induced by H2O2.Procyanidine increased Bcl-2 expression and decreased of Bax expression in PC12 induced by H2O2. Conclusion :Procyanidine can inhibit the apoptosis of PC12 induced by H2O2,which might be correlated with increasing Bcl-2 expression and decreasing Bax expression.
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Protective effect of procyanidine on PC12 cells injury induced by H2O2

  • 1. Department of Pharmacy, Zhejiang Xiaoshan Hospital;Hangzhou 311201, China
  • 2. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
  • Received Date: 2009-07-08

Abstract: Objective :To investigate the protective effect of procyanidine on the injury of PC12 cells induced by H2O2. Methods :The PC12 cells were injuried induced by H2O2.The cel1 activity was determined by MTT.The cell apoptosis rate were detected by flow cytometry.Proteins of Bcl-2 and Bax were detected by immunohistochemistry. Results :Procyanidine increased the survival rate and decreased the apoptotic rate of PC12 induced by H2O2.Procyanidine increased Bcl-2 expression and decreased of Bax expression in PC12 induced by H2O2. Conclusion :Procyanidine can inhibit the apoptosis of PC12 induced by H2O2,which might be correlated with increasing Bcl-2 expression and decreasing Bax expression.

JIANG Guo-jun, LU Ming-Zhu, YI Jia. Protective effect of procyanidine on PC12 cells injury induced by H2O2[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 414-416,420.
Citation: JIANG Guo-jun, LU Ming-Zhu, YI Jia. Protective effect of procyanidine on PC12 cells injury induced by H2O2[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 414-416,420.
shu

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