An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester
- Received Date: 2009-04-03
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Key words:
- L-DOPA /
- L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester /
- synthesis
Abstract: Objective :To improve the synthetic process of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester. Methods :The target molecular was prepared from L-DOPA by using a "half-purified" method.The disposition technics were optimized. Results :The synthetic process offers a simple,easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate.The overall yield is 45.4%. Conclusion :The optimized synthetic process is easy to operate and suitable for large-scale production.
Citation: | LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447. |