Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 6
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(6): 445-447

LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
Citation: LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
shu

An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2009-04-03
  • Objective :To improve the synthetic process of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester. Methods :The target molecular was prepared from L-DOPA by using a "half-purified" method.The disposition technics were optimized. Results :The synthetic process offers a simple,easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate.The overall yield is 45.4%. Conclusion :The optimized synthetic process is easy to operate and suitable for large-scale production.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2248) PDF downloads(658) Cited by()

Related
Proportional views

An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester

  • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2009-04-03

Abstract: Objective :To improve the synthetic process of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester. Methods :The target molecular was prepared from L-DOPA by using a "half-purified" method.The disposition technics were optimized. Results :The synthetic process offers a simple,easy disposal procedure which can effectively reduce the oxidation of raw material and intermediate.The overall yield is 45.4%. Conclusion :The optimized synthetic process is easy to operate and suitable for large-scale production.

LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
Citation: LIU Na, Lü Jia-guo, ZHOU You-jun, ZHU Jü. An efficient method for the synthesis of L-2-(N-Boc)-3′,4′-dimethoxyphenylalanine ethyl ester[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 445-447.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return