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QIAO Liye, FANG Li, CAO Yanli, LU Yin, SU Hua, WANG Shudong. Determination of aloe-emodin,rhein,emodin,chrysophanol and physcion in Xinbaoshen tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 438-440. doi: 10.3969/j.issn.1006-0111.2015.05.015
Citation: ZHOU Xin, ZHANG Ming-xin, ZHANG Jing, SONG Hong-tao. Determianation of plasma concentration of sodium ferulate by HPLC and study on its pharmacokinetics in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 451-454.

Determianation of plasma concentration of sodium ferulate by HPLC and study on its pharmacokinetics in Beagle dogs

  • Received Date: 2009-05-21
  • Objective :To establish a high-performance liquid chromatography method for analysis of sodium ferulate in Beagle dog plasma and to study the pharmacokinetics of sodium ferulate tablets. Methods :Sodium ferulate in plasma was extracted with methyl alcohol,separated on a Kromasil C18 column(200mm×4.6mm,5μm) and the peak height ratio of sodium ferulate to the internal standard tinidazole was measured.Plasma concentration of sodium ferulate was determined at 320 nm using 0.1% acetic acid solution:acetonitrile(80:20) as the mobile phase and the flow rate was 1.0 mL/min. Results :Sodium ferulate was linear in the range of 0.04~25.0 μg/mL(r=0.999 6).The recovery of sodium ferulate was in the range of 94.0%~103.6%.The ABSolute recovery was more than 70%.The relative standard deviations of intra-day and inter-days were less than 10%.The minimum detectable concentration of sodium ferulate was 4.12 ng/mL.The plasma concentration-time curve of sodium ferulate oral tablet was found to be two-compartment model,and t1/2(α) was(0.208±0.045) h,t1/2(β) was(2.228±0.927) h. Conclusion :The method is sensitive,specific for the quantitative determination of sodium ferulate in the plasma of Beagle dog.It is suitable for pharmacokinetics study of sodium ferulate.
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Determianation of plasma concentration of sodium ferulate by HPLC and study on its pharmacokinetics in Beagle dogs

Abstract: Objective :To establish a high-performance liquid chromatography method for analysis of sodium ferulate in Beagle dog plasma and to study the pharmacokinetics of sodium ferulate tablets. Methods :Sodium ferulate in plasma was extracted with methyl alcohol,separated on a Kromasil C18 column(200mm×4.6mm,5μm) and the peak height ratio of sodium ferulate to the internal standard tinidazole was measured.Plasma concentration of sodium ferulate was determined at 320 nm using 0.1% acetic acid solution:acetonitrile(80:20) as the mobile phase and the flow rate was 1.0 mL/min. Results :Sodium ferulate was linear in the range of 0.04~25.0 μg/mL(r=0.999 6).The recovery of sodium ferulate was in the range of 94.0%~103.6%.The ABSolute recovery was more than 70%.The relative standard deviations of intra-day and inter-days were less than 10%.The minimum detectable concentration of sodium ferulate was 4.12 ng/mL.The plasma concentration-time curve of sodium ferulate oral tablet was found to be two-compartment model,and t1/2(α) was(0.208±0.045) h,t1/2(β) was(2.228±0.927) h. Conclusion :The method is sensitive,specific for the quantitative determination of sodium ferulate in the plasma of Beagle dog.It is suitable for pharmacokinetics study of sodium ferulate.

QIAO Liye, FANG Li, CAO Yanli, LU Yin, SU Hua, WANG Shudong. Determination of aloe-emodin,rhein,emodin,chrysophanol and physcion in Xinbaoshen tablets by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 438-440. doi: 10.3969/j.issn.1006-0111.2015.05.015
Citation: ZHOU Xin, ZHANG Ming-xin, ZHANG Jing, SONG Hong-tao. Determianation of plasma concentration of sodium ferulate by HPLC and study on its pharmacokinetics in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(6): 451-454.

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