Influence of danshensu on hemodynamics of anesthetic dog

Key words: 
• danshensu-sodium injection /
• hemodynamics /
• dog

Abstract: Objective To observe the influence of danshensu-sodium injection on the hemodynamics of anesthetic dog including heart rate,blood pressure,cardiac systolic/diastolic function. Methods The hemodynamics of dog after injected danshensu-sodium injection(2,4,8 mg/kg)were measured by cardiac catheter method respectively.Hemodynamics index such as heart rate(HR)、systolic arterial pressure(SAP)、diastolic arterial pressure(DAP)、mean arterial pressure(MAP)、left ventricular systolic pressure(LVSP)、mean left ventricular pressure(MLVP)、the maximal change rate of left intraventricular pressure(±dp/dt_max)、and left ventricular end diastolic pressure(LVEDP)was analysed. Results Danshensu-sodium injection can increase LVSP、±dp/dtmax remarkably,has no significant influence on SAP、DAP、MDP.And heart rate slows down obiviously in the high dosage group. Conclusion Danshensu-sodium injection can improve the cardiac function significantly through decreasing cardiac load and myocardial consumption of oxygen.