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Volume 28 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(3): 181-183,234

TIAN Mou-lia, LI Tie-junb, LIU Hua, ZOU Zuia, SHI Xue-yina. Study on the protection mechanism of UTP against cerebral ischemia reperfusion injury in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 181-183,234.
Citation: TIAN Mou-lia, LI Tie-junb, LIU Hua, ZOU Zuia, SHI Xue-yina. Study on the protection mechanism of UTP against cerebral ischemia reperfusion injury in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 181-183,234.
shu

Study on the protection mechanism of UTP against cerebral ischemia reperfusion injury in rats

  • 1.

    Department of Anesthesiology,Changzheng Hospital,Second Military Medical University,Shanghai 200433,China

  • 2.

    Department of Pharmacology,School of Pharmacy,Second Military Medical University;Shanghai 200433,China

  • Received Date: 2010-01-04
  • Rev Recd Date: 2010-03-07
  • Objective To observe the protective effect of uridine 5'-triphosphate(UTP) on cerebral ischemia reperfusion(IR) injury in rats. Methods The injury model of middle cerebral artery occlusion(MCAO) was established by suture method.UTP were delivered through tail venousr via microinfusion pump 30 min after the occlusion of MCA at a rate of 5 ml/(kg·min).Neurological deficit score(NDS) and brain water content were determined 24 h after reperfusion.The effect of UTP on the contraction of rat arteria carotis in vitro was examined. Results The protective effect of UTP on cerebral ischemia reperfusion showed a dose-dependent relationship.The 90 μg/kg group of UTP had the best protective effect among the 3 groups.The effect of UTP on the contraction of rat arteria carotis in vitro showed that UTP can significantly reduce the blood vessel tension induced by PE. Conclusion UTP has a dose-dependent protective effect on cerebral IR,which may be related to the expansion of the blood vessels of the infarct area.
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Study on the protection mechanism of UTP against cerebral ischemia reperfusion injury in rats

  • 1. Department of Anesthesiology,Changzheng Hospital,Second Military Medical University,Shanghai 200433,China
  • 2. Department of Pharmacology,School of Pharmacy,Second Military Medical University;Shanghai 200433,China
  • Received Date: 2010-01-04
  • Rev Recd Date: 2010-03-07

Abstract: Objective To observe the protective effect of uridine 5'-triphosphate(UTP) on cerebral ischemia reperfusion(IR) injury in rats. Methods The injury model of middle cerebral artery occlusion(MCAO) was established by suture method.UTP were delivered through tail venousr via microinfusion pump 30 min after the occlusion of MCA at a rate of 5 ml/(kg·min).Neurological deficit score(NDS) and brain water content were determined 24 h after reperfusion.The effect of UTP on the contraction of rat arteria carotis in vitro was examined. Results The protective effect of UTP on cerebral ischemia reperfusion showed a dose-dependent relationship.The 90 μg/kg group of UTP had the best protective effect among the 3 groups.The effect of UTP on the contraction of rat arteria carotis in vitro showed that UTP can significantly reduce the blood vessel tension induced by PE. Conclusion UTP has a dose-dependent protective effect on cerebral IR,which may be related to the expansion of the blood vessels of the infarct area.

TIAN Mou-lia, LI Tie-junb, LIU Hua, ZOU Zuia, SHI Xue-yina. Study on the protection mechanism of UTP against cerebral ischemia reperfusion injury in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 181-183,234.
Citation: TIAN Mou-lia, LI Tie-junb, LIU Hua, ZOU Zuia, SHI Xue-yina. Study on the protection mechanism of UTP against cerebral ischemia reperfusion injury in rats[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(3): 181-183,234.
shu

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